Early life stress and blood pressure levels in late adulthood.

Journal of Human Hypertension
Hanna AlastaloJ G Eriksson

Abstract

Severe stress experienced in early life may have long-term consequences on adult physiological functions. We studied the long-term effects of separation on blood pressure levels in non-obese subjects who were separated temporarily in childhood from their parents during World War II (WWII). The original clinical study cohort consists of people born during 1934-1944 in Helsinki, Finland. This substudy includes 1361 non-obese subjects (body mass index <30 kg m(-2)). Of these, 192 (14.1%) had been evacuated abroad during WWII. The remaining subjects served as controls. Blood pressure levels and use of blood pressure medication were studied. The separated subjects had significantly higher systolic blood pressure values than the non-separated (148.6+21.5 vs 142.2+19.6 mm Hg, P<0.0001) in adult life. Those subjects separated in early childhood had markedly higher systolic and diastolic blood pressure values in adult life compared with the non-separated (154.6 vs 142.5 mm Hg; 95% confidence interval (CI) 2.6-14.7; P<0.005 and 90.8 vs 87.7 mm Hg; 95% CI 1.0-7.3; P<0.02, respectively). Systolic blood pressure was also higher in the group separated for a duration of <1 year (151.7 vs 142.2 mm Hg; 95% CI 0.0-12.4; P<0.05) compared with the...Continue Reading

References

Feb 1, 1992·Journal of Hypertension·A F Lever, S B Harrap
Sep 27, 1993·Archives of Internal Medicine·B S McEwen, E Stellar
Apr 1, 1999·Journal of Hypertension·T J RoseboomO P Bleker
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Oct 28, 2005·The New England Journal of Medicine·David J P BarkerJohan G Eriksson
Apr 25, 2007·Hypertension·Johan G ErikssonDavid J P Barker
Sep 19, 2007·American Journal of Epidemiology·Anu-Katriina PesonenJohan G Eriksson
Jul 24, 2008·European Heart Journal·Alexander JonesDavid I W Phillips
Aug 23, 2008·Annals of Medicine·Hanna AlastaloJohan G Eriksson
May 20, 2009·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Barbara J LehmanTeresa E Seeman

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Citations

Jul 19, 2013·PloS One·Hanna AlastaloJohan G Eriksson
May 17, 2013·International Journal of Behavioral Medicine·Nicholas W J WainwrightKay-Tee Khaw
Jul 28, 2016·Neuroscience and Biobehavioral Reviews·M O MurphyA S Loria
Aug 5, 2014·Physiology & Behavior·Seico BennerChiharu Tohyama
Nov 29, 2016·Psychosomatic Medicine·Allison A AppletonMelissa Tracy
Jan 19, 2019·British Journal of Pharmacology·Ijeoma E ObiJennifer S Pollock
Jan 1, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Mia ErikssonJohan G Eriksson
Aug 22, 2018·Population Research and Policy Review·Maria E BleilAprile D Benner
Nov 23, 2019·Journal of the American Heart Association·Carolina DalmassoAnalia S Loria
Oct 15, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rebecca E Lacey, Helen Minnis
Aug 25, 2020·Journal of Health Psychology·Anna JanůPeter Tavel
Aug 25, 2020·Psychosomatic Medicine·Margaret H BublitzGhada Bourjeily
Feb 28, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Dao H HoJennifer S Pollock
Oct 25, 2016·Physiological Research·A Puzserova, I Bernatova
Oct 4, 2017·American Journal of Physiology. Renal Physiology·Carmen De MiguelJennifer S Pollock
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Caroline H D Fall, Kalyanaraman Kumaran
Sep 16, 2015·American Journal of Physiology. Heart and Circulatory Physiology·John J Reho, Steven A Fisher
Jun 21, 2021·The Journal of Pediatrics·Joanne L AndradeMichelle I Cardel
Jun 22, 2021·Frontiers in Psychology·Maria E BleilCathryn Booth-LaForce
Jan 13, 2021·Current Pediatric Reviews·Isabella Barreto S MachadoAna Cristina Simões E Silva

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