Early life stress and hippocampal neurogenesis in the neonate: sexual dimorphism, long term consequences and possible mediators

Frontiers in Molecular Neuroscience
Naima Lajud, Luz Torner

Abstract

Adverse early life experience decreases adult hippocampal neurogenesis and results in increased vulnerability to neuropsychiatric disorders. Despite that the effects of postnatal stress on neurogenesis have been widely studied in adult individuals, few efforts have been done to evaluate its immediate effects on the developing hippocampus. Moreover, it is not clear whether postnatal stress causes a differential impact in hippocampus development in male and female neonates that could be related to emotional deficits in adulthood. It has been proposed that the long term effects of early stress exposure rise from a persistent HPA axis activation during sensitive time windows; nevertheless the exact mechanisms and mediators remain unknown. Here, we summarize the immediate and late effects of early life stress on hippocampal neurogenesis in male and female rat pups, compare its later consequences in emotionality, and highlight some relevant mediator peptides that could be potentially involved in programming.

References

Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P TanapatE Gould
Dec 22, 1999·Biological Psychiatry·E Gould, P Tanapat
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·V LemaireD N Abrous
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Aug 3, 2002·The American Journal of Psychiatry·D Jeffrey NewportCharles B Nemeroff
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Ora Kofman
Jun 5, 2003·Molecular Neurobiology·Kristen L BrunsonTallie Z Baram
Jul 27, 2004·Nature Neuroscience·Christian MirescuElizabeth Gould
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·E Ronald de KloetMathias Schmidt
May 14, 2005·Nature Reviews. Neuroscience·E Ron de KloetFlorian Holsboer
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul M PlotskyMichael J Meaney
Mar 13, 2008·The European Journal of Neuroscience·Jian-Min ZhangMargaret M McCarthy
Feb 12, 2009·Journal of Neuroendocrinology·T Kikusui, Y Mori
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luz TornerInga D Neumann
Mar 5, 2009·Cellular and Molecular Neurobiology·Eniko RacekováJudita Orendácová
Mar 19, 2009·Neurobiology of Learning and Memory·Rosemary C BagotMarian Joëls
Jun 19, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Pinar KarakaşSait Polat
Jan 19, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sadia OrelandChris Pickering
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte A OomenHarm Krugers
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Autumn S IvyTallie Z Baram
Oct 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Claudia VegaCarmen Clapp

❮ Previous
Next ❯

Citations

Sep 1, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Eunice Y YuenZhen Yan
Oct 26, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Susan CohenRobert Lane
Jul 31, 2016·Experimental Physiology·Nikita N BurkeTuan Trang
Jan 24, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kit-Yi YamAniko Korosi
Feb 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mirai YamazakiKoji Ohashi
Jul 18, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiroya YamadaShuji Hashimoto
Jun 4, 2020·Biology of Sex Differences·Katherine E Kight, Margaret M McCarthy
Feb 22, 2017·International Journal of Molecular Sciences·Adel JunglingAndrea Tamas
May 12, 2017·Frontiers in Cellular Neuroscience·Danielle J HouwingJocelien D A Olivier
Dec 4, 2020·Genetics·L Ryan Baugh, Patrick J Hu
Feb 26, 2021·Experimental Neurology·Diego Bulcão ViscoRaul Manhães-de-Castro
May 10, 2019·Psychiatry Research. Neuroimaging·Deanna M BarchJoan L Luby
May 7, 2021·Genetics·L Ryan Baugh, Patrick J Hu
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Helen EachusSoojin Ryu
Aug 28, 2021·Frontiers in Molecular Neuroscience·Jorge A Sierra-FonsecaKristin L Gosselink
Jun 19, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Débora da Silva Bandeira RêgoAna Teresa Figueiredo Stochero Leslie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.