Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Brain, Behavior, and Immunity
Hyong Jin ChoMichael R Irwin

Abstract

Fatigue is highly prevalent and causes serious disruption in quality of life. Although cross-sectional studies suggest childhood adversity is associated with adulthood fatigue, longitudinal evidence of this relationship and its specific biological mechanisms have not been established. This longitudinal study examined the association between early life stress and adulthood fatigue and tested whether this association was mediated by low-grade systemic inflammation as indexed by circulating C-reactive protein (CRP) and interleukin-6 (IL-6). In the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based longitudinal study conducted in 4 US cities, early life stress was retrospectively assessed in 2716 African-American and white adults using the Risky Families Questionnaire at Year 15 examination (2000-2001, ages 33-45 years). Fatigue as indexed by a loss of subjective vitality using the Vitality Subscale of the 12-item Short Form Health Survey was assessed at both Years 15 and 20. While CRP was measured at both Years 15 and 20, IL-6 was measured only at Year 20. Early life stress assessed at Year 15 was associated with adulthood fatigue at Year 20 after adjustment for sociodemographic characteristics, bo...Continue Reading

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Citations

Sep 14, 2013·Sports Medicine·Matthew A Stults-Kolehmainen, Rajita Sinha
Sep 12, 2012·Brain, Behavior, and Immunity·Julienne E Bower
Oct 13, 2014·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Margaret A EgeLewis P Krain
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Jan 1, 2014·Clinical Psychological Science : a Journal of the Association for Psychological Science·Julienne E BowerGeorge M Slavich
May 2, 2017·Journal of Child and Family Studies·Jeffrey P WinerPaula R Pietromonaco
Apr 4, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mimi TangRuili Dang
Sep 26, 2021·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Karen A KalmakisLisa M Chiodo
Oct 5, 2021·Journal of Racial and Ethnic Health Disparities·Tiffany GreenNao Hagiwara

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