Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei

Biological Psychiatry
Ronald A CohenLeanne M Williams

Abstract

Early life stress (ELS) is linked to adult psychopathology and may contribute to long-term brain alterations, as suggested by studies of women who suffered childhood sexual abuse. We examine whether reported adverse ELS defined as stressful and/or traumatic adverse childhood events (ACEs) is associated with smaller limbic and basal ganglia volumes. 265 healthy Australian men and women without psychopathology or brain disorders were studied. ACEs were assessed by the ELSQ and current emotional state by the DASS. Anterior cingulate cortex (ACC), hippocampus, amygdala, and caudate nucleus volumes were measured from T1-weighted MRI. Analyses examined ROI volumetric associations with reported ACEs and DASS scores. Participants with greater than two ACEs had smaller ACC and caudate nuclei than those without ACEs. A significant association between total ACEs and ROI volumes for these structures was observed. Regression analysis also revealed that ELS was more strongly associated than current emotional state (DASS) with these ROI volumes. Reported ELS is associated with smaller ACC and caudate volumes, but not the hippocampal or amygdala volumes. The reasons for these brain effects are not entirely clear, but may reflect the influence ...Continue Reading

References

Jun 21, 1997·Annals of the New York Academy of Sciences·B S McEwen, A M Magarinos
Mar 1, 1995·Child Abuse & Neglect·B Sanders, E Becker-Lausen
Dec 24, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·D B ClarkA M Hegedus
Oct 27, 1998·Human Brain Mapping·J AshburnerK Friston
Feb 16, 1999·Depression and Anxiety·M B HamnerM S George
Apr 15, 1999·Biological Psychiatry·J D Bremner
May 11, 1999·Trends in Cognitive Sciences·R J Davidson, W Irwin
May 14, 1999·Current Opinion in Neurobiology·R J DavidsonK Putnam
Sep 17, 1999·Neurology·R A CohenH Wilkinson
Nov 30, 1999·JAMA : the Journal of the American Medical Association·R F AndaG A Giovino
Nov 26, 1999·The Journal of Neuropsychiatry and Clinical Neurosciences·R A CohenH Wilkinson
Apr 19, 2000·Human Brain Mapping·J AshburnerK J Friston
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Jul 6, 2000·The Australian and New Zealand Journal of Psychiatry·A L Beautrais
Oct 20, 2001·Journal of Child and Adolescent Psychopharmacology·M D De BellisK A Harenski
Mar 14, 2002·Physiology & Behavior·Larissa N MaslovaNina K Popova
Jul 13, 2002·Biological Psychiatry·Gerardo VillarrealWilliam M Brooks
Aug 6, 2002·Psychiatric Services : a Journal of the American Psychiatric Association·Robert F AndaDavid F Williamson
Oct 16, 2002·Nature Neuroscience·Mark W GilbertsonRoger K Pitman
Mar 29, 2003·Psychiatric Services : a Journal of the American Psychiatric Association·Jean S GearonAlan S Bellack
Jun 27, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Evian Gordon
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·H YamasueN Kato
Oct 4, 2003·Psychotherapy and Psychosomatics·Willeke H van ZelstRichard van Dyck
Dec 19, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Mario SperanzaPhilippe Jeammet
Jan 1, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Linda L CarpenterLawrence H Price
Apr 6, 2004·The Psychiatric Clinics of North America·Matthew Kimble, Milissa Kaufman

❮ Previous
Next ❯

Citations

Jun 3, 2009·Archives of General Psychiatry·Simona SpinelliElliot Stein
Dec 8, 2011·Archives of Pediatrics & Adolescent Medicine·Erin E EdmistonHilary P Blumberg
Apr 25, 2013·European Archives of Psychiatry and Clinical Neuroscience·Alexander JatzkoAndrea Schmitt
Jan 19, 2012·Brain Structure & Function·Aisling O'Neill, Thomas Frodl
Jul 20, 2011·European Child & Adolescent Psychiatry·Corina BenjetMaria Elena Medina-Mora
May 12, 2009·Neuropsychology Review·Pauline M Maki, Eileen Martin-Thormeyer
Dec 19, 2012·Brain Imaging and Behavior·Laurie M BakerRobert H Paul
Dec 18, 2013·Development and Psychopathology·Terrie E Moffitt, UNKNOWN Klaus-Grawe 2012 Think Tank
May 25, 2012·Journal of the International Neuropsychological Society : JINS·Uraina S ClarkKaren T Tashima
Jan 13, 2010·Psychological Review·Barbara L GanzelElaine Wethington
Jan 16, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L C GilesV M Moore
Jul 11, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda J LawPaul J Harrison
Feb 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leanne M WilliamsEvian Gordon
Nov 15, 2011·Cerebral Cortex·Marloes J A G HenckensGuillén Fernández
Apr 18, 2008·Social Cognitive and Affective Neuroscience·Peter J GianarosAhmad R Hariri
May 26, 2010·Psychosomatic Medicine·Peter J Gianaros, Stephen B Manuck
Jan 22, 2009·Psychiatry and Clinical Neurosciences·Andrea Parolin JackowskiJoan Kaufman
Sep 28, 2013·PloS One·Mayuresh S KorgaonkarStuart M Grieve
May 29, 2013·Journal of Psychiatry & Neuroscience : JPN·Su LuiQi-Yong Gong
Jul 20, 2010·Annual Review of Psychology·Karen A Matthews, Linda C Gallo
May 21, 2013·Social Cognitive and Affective Neuroscience·Sabine AustMalek Bajbouj
Mar 29, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca K SripadaIsrael Liberzon
Feb 3, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Martin H Teicher, Jacqueline A Samson
Oct 23, 2013·Epilepsy & Behavior : E&B·Jolien S van CampenMarian Joels
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Katie A McLaughlinHilary K Lambert
Feb 2, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ji Sun Kim, Seung-Hwan Lee
Jun 15, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·L SideliM Di Forti
Apr 25, 2013·Biological Psychiatry·Elysia Poggi DavisKevin Head

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.