Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice

Progress in Neuro-psychopharmacology & Biological Psychiatry
Dominik P KiserOlga Rivero

Abstract

Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the presynaptic compartment of inhibitory GABAergic synapses in the hippocampus and Cdh13 knockout mice show an increased inhibitory drive onto hippocampal CA1 pyramidal neurons, leading to a shift in excitatory/inhibitory balance. CDH13 is also moderating migration of serotonergic neurons in the dorsal raphe nucleus, establishing projections preferentially to the thalamus and cerebellum during brain development. Furthermore, CDH13 is upregulated by chronic stress as well as in depression, suggesting a role in early-life adaptation to stressful experience. Here, we therefore investigated the interaction between Cdh13 variation and neonatal maternal separation (MS) in mice. Male and female wild-type (Cdh13+/+), heterozygous (Cdh13+/-) and homozygous (Cdh13-/-) knockout mice exposed to MS, or daily handling as control, were subjected to a battery of behavioural tests to assess motor activity, learning and memory as well as anxiety-...Continue Reading

Citations

Jun 30, 2019·The Proceedings of the Nutrition Society·Marion Rincel, Muriel Darnaudéry
Dec 8, 2020·Frontiers in Molecular Neuroscience·Irina KozlovaVladimir Sytnyk
Dec 10, 2019·Current Opinion in Behavioral Sciences·Shannon L GillespieLisa M Christian
Jul 9, 2021·Fish Physiology and Biochemistry·Ehsan Pashay AhiMonika Schmitz

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