Early life stress impairs fear conditioning in adult male and female rats

Brain Research
Therese A KostenJeansok J Kim

Abstract

We demonstrated that neonatal isolation (1-h pup isolation; postnatal days 2-9) impairs context-induced fear conditioning in adult male rats and tends to enhance this effect and foot shock sensitivity in females. In this study, we examine the effects of brief (i.e., handling; 15 min) and prolonged (3 h) maternal separations (postnatal days 1-21) on fear conditioning and foot shock sensitivity in adult male and female rats. Identical training and test conditions from our prior study were employed so comparisons of the three early life stressors could be made. Context- and cue-elicited freezing and ultrasonic vocalizations (USVs; 22 kHz) were measured after 10 tone-shock training trials in Experiment 1. In Experiment 2, foot shock responses (flinch, jump, sonic vocalizations) to escalating shock levels were assessed. Brief maternal separation impaired context- and cue-conditioned fear in rats of both sexes as assessed by USVs. Prolonged maternal separation only impaired context fear in female rats. There were no effects on foot shock sensitivity. Results of this and other studies suggest that early life stress impairs fear conditioning in adult rats whereas stress experienced in adulthood has the opposite effect. These opposing e...Continue Reading

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Citations

Feb 19, 2011·Psychopharmacology·Li WangStephanie C Dulawa
Jan 25, 2008·Bulletin of Experimental Biology and Medicine·A E UmriukhinK V Sudakov
Mar 23, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R K W Schwarting, M Wöhr
Jul 2, 2014·PloS One·Arun AsokTania L Roth
Feb 5, 2014·Pharmacology, Biochemistry, and Behavior·Nicole L T MooreRaymond F Genovese
Aug 2, 2014·Behavioural Brain Research·Dayalan SampathT R Laxmi
Apr 12, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Therese A Kosten, David A Nielsen
Jun 7, 2006·Stress : the International Journal on the Biology of Stress·Jeansok J KimTherese A Kosten
Feb 10, 2016·Frontiers in Behavioral Neuroscience·Sofia KanatsouMarian Joëls
Aug 4, 2011·Neurobiology of Learning and Memory·James DachtlerMark A Good
Apr 21, 2010·Neurobiology of Learning and Memory·Kathryn A FrankolaGary P Dohanich
Mar 11, 2009·Physiology & Behavior·Christina Dalla, Tracey J Shors
Nov 11, 2008·Behavioural Brain Research·Carl W StevensonCharles A Marsden
Nov 7, 2007·Biological Psychiatry·Linda C Mayes
Mar 14, 2007·Progress in Neurobiology·Fabio FumagalliMarco Andrea Riva
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Jun 21, 2012·Developmental Psychobiology·Nim Tottenham
Apr 25, 2014·British Journal of Pharmacology·D Joel, R Yankelevitch-Yahav
Aug 19, 2014·Journal of the Experimental Analysis of Behavior·Megan E OlshavskyHongjoo J Lee
Aug 19, 2014·Developmental Psychobiology·Charlis RainekiJoanne Weinberg
Dec 14, 2011·Stress : the International Journal on the Biology of Stress·Nicole YeeMarkus Wöhr
Jul 24, 2012·Neuroscience and Biobehavioral Reviews·Therese A KostenHongjoo J Lee
Feb 22, 2014·Behavioural Brain Research·Joanna Danielewicz, Grzegorz Hess

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