Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse.

Diabetologia
C H F HansenA K Hansen

Abstract

Increasing evidence suggests that environmental factors changing the normal colonisation pattern in the gut strongly influence the risk of developing autoimmune diabetes. The aim of this study was to investigate, both during infancy and adulthood, whether treatment with vancomycin, a glycopeptide antibiotic specifically directed against Gram-positive bacteria, could influence immune homeostasis and the development of diabetic symptoms in the NOD mouse model for diabetes. Accordingly, one group of mice received vancomycin from birth until weaning (day 28), while another group received vancomycin from 8 weeks of age until onset of diabetes. Pyrosequencing of the gut microbiota and flow cytometry of intestinal immune cells was used to investigate the effect of vancomycin treatment. At the end of the study, the cumulative diabetes incidence was found to be significantly lower for the neonatally treated group compared with the untreated group, whereas the insulitis score and blood glucose levels were significantly lower for the mice treated as adults compared with the other groups. Mucosal inflammation was investigated by intracellular cytokine staining of the small intestinal lymphocytes, which displayed an increase in cluster of d...Continue Reading

References

Jan 1, 1992·Autoimmunity·K BuschardK Bendtzen
Jun 1, 1987·The Journal of Experimental Medicine·L S WickerM C Appel
May 1, 1993·Immunology Today·P PozzilliP E Beales
Feb 5, 1999·European Journal of Immunology·M R KarlssonU I Dahlgren
Apr 21, 1999·Clinical and Experimental Immunology·E SavilahtiH K Akerblom
May 8, 1999·The American Journal of Clinical Nutrition·J J Cebra
Mar 22, 2002·Nature Reviews. Immunology·M Wills-KarpC L Karp
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N SudoC Kubo
Sep 20, 2002·The New England Journal of Medicine·Jean-Francois Bach
May 26, 2004·Immunology Letters·Helena Tlaskalová-HogenováAlena Kokesová
Dec 16, 2005·Diabetes/metabolism Research and Reviews·Axel Kornerup HansenKarsten Buschard
Oct 7, 2006·Current Opinion in Gastroenterology·A M Mowat
Dec 18, 2007·Applied and Environmental Microbiology·Muriel DerrienWillem M de Vos
May 8, 2008·Clinical and Experimental Immunology·H IshikawaT Matsumoto
Mar 6, 2009·Mucosal Immunology·K Honda, K Takeda
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Dec 8, 2009·Journal of Autoimmunity·June L RoundSarkis K Mazmanian
Apr 27, 2010·Clinical and Experimental Immunology·H OkadaJ-F Bach
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·June L Round, Sarkis K Mazmanian
Jul 22, 2010·The American Journal of Gastroenterology·Chin Wen PngTimothy H J Florin
Jul 23, 2011·Frontiers in Microbiology·Nicola C Reading, Dennis L Kasper

❮ Previous
Next ❯

Citations

Aug 13, 2013·Current Diabetes Reports·Outi Vaarala
Sep 24, 2013·Trends in Immunology·Maja Wållberg, Anne Cooke
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Apr 26, 2013·Briefings in Functional Genomics·Patrice D Cani
Sep 28, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Alexander Neef, Yolanda Sanz
Mar 29, 2013·Science Translational Medicine·Alice P LiouLee M Kaplan
Oct 12, 2012·PloS One·Katja Maria Bangsgaard BendtsenAxel Kornerup Hansen
Jan 1, 2012·The Review of Diabetic Studies : RDS·Outi Vaarala
Mar 13, 2014·International Journal of Molecular Sciences·Omotayo O ErejuwaMohd S Ab Wahab
Nov 8, 2013·Seminars in Immunopathology·Shinji Fukuda, Hiroshi Ohno
Jun 4, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Francis OkekeGerard E Mullin
May 30, 2014·Diabetologia·Julie C AntvorskovKarsten Buschard
Nov 26, 2014·Nature Communications·Michael RoggenbuckLars H Hansen
Jun 22, 2014·Extremophiles : Life Under Extreme Conditions·Aviaja L HauptmannNikolaj Blom
Feb 16, 2016·Microbial Pathogenesis·Muriel DerrienWillem M de Vos
Jan 6, 2016·Nature Reviews. Endocrinology·Mikael Knip, Heli Siljander
Apr 22, 2014·FEBS Letters·Dennis S NielsenAxel K Hansen
Feb 26, 2016·Journal of Autoimmunity·Alexandra PaunJayne S Danska
Feb 25, 2014·Gastroenterology·Max NieuwdorpLee M Kaplan
Nov 9, 2012·European Journal of Immunology·Camilla H F HansenSøren Skov
Sep 26, 2015·Journal of Autoimmunity·James A PearsonLi Wen
Jan 9, 2016·Gut Microbes·Randi LundbergCamilla H F Hansen
Jun 9, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Elke GüldenLi Wen
Jun 14, 2015·The Journal of Nutritional Biochemistry·Geoffrey A PreidisJoseph F Petrosino
Jan 20, 2016·Journal of Diabetes Research·Dina Silke Malling DamlundHanne Frøkiær
Aug 2, 2014·Scientific Reports·Merete EllekildeCamilla H F Hansen
Jul 30, 2014·Molecular Ecology·Saria OtaniMichael Poulsen
Sep 2, 2015·ILAR Journal·Axel Kornerup HansenCamilla Hartmann Friis Hansen
Apr 25, 2015·Molecular Ecology·Joanito LibertiJacobus J Boomsma
May 9, 2015·Pediatric Diabetes·Joseph G Daft, Robin G Lorenz
Oct 2, 2013·Journal of Microbiological Methods·Peter N HolmsgaardLars H Hansen
Sep 9, 2015·Journal of Diabetes Research·Camila Leal-LopesRicardo G Correa
May 10, 2015·Diabetologia·Austin G Davis-Richardson, Eric W Triplett
Mar 10, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Changyun HuLi Wen
Mar 31, 2015·Nutrition Research·Canxia HeWei Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.