Early lung function abnormalities in acromegaly

Lung
A BenfanteN Scichilone

Abstract

Acromegaly is an insidious disorder caused by a pituitary growth hormone (GH)-secreting adenoma resulting in high circulating levels of GH and insulin-like growth factor I (IGF-I). Respiratory disorders are common complications in acromegaly, and can severely impact on quality of life, eventually affecting mortality. The present study aimed to explore structural and functional lung alterations of acromegalic subjects. We enrolled 10 consecutive patients (M/F: 5/5) affected by acromegaly. In all patients, magnetic resonance imaging (MRI) revealed the presence of pituitary tumor. All patients underwent clinical, lung functional, biological, and radiological assessments. Ten healthy age-matched subjects also served as controls. No statistically significant differences in lung function were detected between acromegalic and healthy subjects (p ≥ 0.05 for all analyses). However, the diffusing capacity for CO (TLCO) was significantly lower in the acromegalic group than in healthy subjects (TLCO% predicted: 78.1 ± 16 vs. 90 ± 6 %, respectively, p = 0.04; KCO% predicted: 77 ± 16 vs. 93 ± 5 %, p = 0.02, respectively). None of the lung function parameters correlated with duration of the disease, or with inflammatory marker of the airways....Continue Reading

References

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Apr 23, 2010·The Journal of Clinical Endocrinology and Metabolism·A GiustinaUNKNOWN Acromegaly Consensus Group
Nov 14, 2013·Multidisciplinary Respiratory Medicine·Gustavo Bittencourt CamiloAgnaldo José Lopes

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Citations

Jan 26, 2016·Expert Opinion on Pharmacotherapy·Luiz Eduardo Wildemberg, Mônica R Gadelha
Apr 23, 2017·European Journal of Endocrinology·Sylvère StörmannMatthias W Angstwurm
Jul 19, 2018·BioMed Research International·Zheng WangXiaoju Zhang

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