Early Lupus Project: one-year follow-up of an Italian cohort of patients with systemic lupus erythematosus of recent onset

Lupus
G D SebastianiA Mathieu

Abstract

Objective To describe the clinical and serological features of a prospectively followed cohort of early diagnosed systemic lupus erythematosus (SLE) patients during a one-year follow-up period. Methods SLE patients with disease duration less than 12 months were consecutively enrolled in a multicentre, prospective study. At study entry and then every 6 months, a large panel of data was recorded. Results Of 260 patients enrolled, 185 had at least 12 months of follow-up; of these, 84.3% were female, 92.4% were Caucasians. Mean diagnostic delay was about 20 months; higher values of European Consensus Lupus Activity Measurement (ECLAM) and of organs/systems involved were both associated with shorter diagnostic delay. Clinical and serological parameters improved after study entry. However, patients' quality of life deteriorated and cardiovascular risk factors significantly increased. About one-third of patients with active disease at study entry went into remission (ECLAM = 0). Negative predictors for remission were: oral ulcers, arthritis, low C4, anti-SSB (Ro) antibodies and therapy with mycophenolate. There was a widespread use of glucocorticoids both at baseline and during follow-up. Conclusion Clinical symptoms and serological p...Continue Reading

References

Dec 1, 1996·Arthritis and Rheumatism·E CirueloJ J Gómez-Reino
Aug 5, 2006·The American Journal of Medicine·Andrea DoriaSilvano Todesco
Dec 18, 2009·Autoimmunity·Yaniv ShererYehuda Shoenfeld
Nov 13, 2012·Annals of the Rheumatic Diseases·Nathalie Costedoat-ChalumeauUNKNOWN Group PLUS
Apr 18, 2014·Annals of the Rheumatic Diseases·Ronald F van VollenhovenMatthias Schneider
Aug 1, 2015·Annals of the Rheumatic Diseases·Margherita ZenAndrea Doria
Oct 30, 2015·Annals of the Rheumatic Diseases·Ronald F van VollenhovenCynthia Aranow
Nov 20, 2015·Nature Reviews. Rheumatology·David S Pisetsky

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Citations

Feb 26, 2020·Lupus Science & Medicine·Nancy J Olsen, David R Karp
Sep 29, 2019·Arthritis Care & Research·Zahi ToumaUNKNOWN ACR/EULAR group, New SLE classification criteria for clinical research are being developed, sponsored by EULAR, ACR
Dec 8, 2019·Best Practice & Research. Clinical Rheumatology·Mariele GattoAndrea Doria

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