Abstract
Recent advances in image guidance and stereotactic body radiotherapy (SBRT) have resulted in unprecedented local control for spinal metastases of all histologies. However, little is known about early imaging biomarkers of local control. This study aimed to identify early magnetic resonance imaging (MRI) biomarkers to predict local control after SBRT for patients with sarcoma spine metastases. This study used a retrospective case series at a large tertiary cancer center. From 2011 to 2014, 9 consecutive patients with 12 metastatic sarcoma lesions to the spine were treated with SBRT and underwent evaluation with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) both pre- and post-SBRT. Changes in perfusion metrics, including the wash-in rate constant (Ktrans), plasma volume (Vp), composite multiparametric magnetic resonance imaging (mpMRI) score, bi-dimensional tumor size, and a graded response assessment were performed and correlated to local control. All measurements were independent and blinded by two neuroradiologists. R2 statistics were performed to document correlation, and two-tailed t tests were used to compare groups. p<.05 was deemed statistically significant. The median time from SBRT until posttreatment M...Continue Reading
References
Aug 27, 1992·The New England Journal of Medicine·T N Byrne
Feb 17, 1994·The New England Journal of Medicine·R Alexanian, M Dimopoulos
Mar 7, 1996·Nature·M VerheijR N Kolesnick
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·P S ToftsR M Weisskoff
Oct 4, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·W M SzeM D Mason
Jul 11, 2006·Physics in Medicine and Biology·S Walker-SamuelD J Collins
Jan 16, 2007·Magnetic Resonance Imaging·Thomas E YankeelovJohn C Gore
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Yoshiya YamadaZvi Fuks
Apr 11, 2008·Neuro-oncology·Alba A BrandesEnrico Franceschi
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Apr 11, 2009·The Orthopedic Clinics of North America·Jonathan H LeeRoy K Aaron
May 19, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steven SourbronKarin Herrmann
Apr 16, 2010·Annals of the New York Academy of Sciences·J P Dyke, R K Aaron
May 23, 2012·International Journal of Radiation Oncology, Biology, Physics·Brett W CoxYoshiya Yamada
Jun 5, 2012·International Journal of Radiation Oncology, Biology, Physics·Marcelo V R CunhaArjun Sahgal
Jul 3, 2013·The Lancet Oncology·Arjun SahgalMichael G Fehlings
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Citations
Dec 31, 2015·Current Treatment Options in Oncology·Carlos H F Chan, Philip Wong
Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Houda BahigLaura Masucci
Aug 17, 2018·PloS One·Hayley M ReynoldsShankar Siva
Oct 20, 2017·Neurosurgery·Salman FaruqiArjun Sahgal
Apr 26, 2019·Topics in Magnetic Resonance Imaging : TMRI·Majid KhanKristin Redmond
Dec 28, 2019·The Journal of International Medical Research·Yu ChenFred R Hirsch
Apr 16, 2020·Journal of Medical Imaging and Radiation Oncology·Siobhra O'SullivanClare Faul
Jan 4, 2017·Neurosurgical Focus·Moaaz SolimanDaniel E Spratt
Apr 30, 2017·Technology in Cancer Research & Treatment·Kiran A KumarYoshiya Yamada
Feb 6, 2020·Clinical and Translational Radiation Oncology·Matthew MouawadNeil Gelman
Apr 6, 2021·Seminars in Ultrasound, CT, and MR·Raul Fernando ValenzuelaColleen M Costelloe
Aug 11, 2021·Medical Physics·Chunhao WangZheng Chang
Aug 19, 2021·Clinical Radiology·Y ChenN Lang
Sep 22, 2021·The British Journal of Radiology·Evanthia KousiMaria A Schmidt