Early magnetic resonance imaging biomarkers to predict local control after high dose stereotactic body radiotherapy for patients with sarcoma spine metastases

The Spine Journal : Official Journal of the North American Spine Society
Daniel E SprattJoseph R Osborne

Abstract

Recent advances in image guidance and stereotactic body radiotherapy (SBRT) have resulted in unprecedented local control for spinal metastases of all histologies. However, little is known about early imaging biomarkers of local control. This study aimed to identify early magnetic resonance imaging (MRI) biomarkers to predict local control after SBRT for patients with sarcoma spine metastases. This study used a retrospective case series at a large tertiary cancer center. From 2011 to 2014, 9 consecutive patients with 12 metastatic sarcoma lesions to the spine were treated with SBRT and underwent evaluation with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) both pre- and post-SBRT. Changes in perfusion metrics, including the wash-in rate constant (Ktrans), plasma volume (Vp), composite multiparametric magnetic resonance imaging (mpMRI) score, bi-dimensional tumor size, and a graded response assessment were performed and correlated to local control. All measurements were independent and blinded by two neuroradiologists. R2 statistics were performed to document correlation, and two-tailed t tests were used to compare groups. p<.05 was deemed statistically significant. The median time from SBRT until posttreatment M...Continue Reading

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Citations

Dec 31, 2015·Current Treatment Options in Oncology·Carlos H F Chan, Philip Wong
Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Houda BahigLaura Masucci
Apr 26, 2019·Topics in Magnetic Resonance Imaging : TMRI·Majid KhanKristin Redmond
Dec 28, 2019·The Journal of International Medical Research·Yu ChenFred R Hirsch
Sep 22, 2021·The British Journal of Radiology·Evanthia KousiMaria A Schmidt

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