Early markers of myocardial ischemia: from the experimental model to forensic pathology cases of sudden cardiac death

International Journal of Legal Medicine
Sara SabatassoTony Fracasso

Abstract

The goal of this study was to assess whether early markers of myocardial ischemia, identified in a previous experimental work, can be applied in forensic pathology cases of sudden, ischemic cardiac death. These markers include desphosphorylated connexin 43 (Cx43), JunB, TUNEL assay, myoglobin, and troponin T. Fourteen cases of sudden cardiac death with gross and/or histological signs of myocardial infarction and 14 cases of sudden cardiac death with signs of early ischemia at histology and positive immunoreactions for fibronectin and C5b-9 were investigated. The control group was represented by 15 hanging (global hypoxia) cases. Immunohistochemical reactions were classified into four degrees and compared among groups. Cx43 and JunB were significantly more expressed in hanging than in ischemia/infarction, but they showed a different distribution in the tissue (sub-endocardial in ischemia/infarction, diffuse in hanging) and a different intensity of the signal. TUNEL assay was significantly more expressed in the group of early ischemia than in myocardial infarction. Myoglobin and troponin T did not show any significantly different expression among the three groups. Depletion markers have a limited application in forensic cases, an...Continue Reading

References

Apr 1, 1992·The Journal of Clinical Investigation·A A KnowltonP Brecher
May 1, 1990·Journal of Molecular and Cellular Cardiology·B V ShekhoninV E Koteliansky
Jan 1, 1990·Zeitschrift für Rechtsmedizin. Journal of legal medicine·H ThomsenS Bhakdi
Feb 1, 1989·Forensic Science International : Synergy·S LeadbeatterB Jasani
Apr 23, 1996·Forensic Science International : Synergy·B J HuJ Z Zhu
Jul 1, 1996·The Journal of Pathology·I E WillemsM J Daemen
Jan 16, 1998·Virchows Archiv : an International Journal of Pathology·T Matsushita, T Takamatsu
Aug 10, 2000·International Journal of Legal Medicine·C OrtmannB Brinkmann
Sep 21, 2001·The American Journal of Forensic Medicine and Pathology·M S Rodríguez-CalvoJ M Suárez-Peñaranda
Apr 2, 2002·International Journal of Legal Medicine·M NakatomeH Inoue
Apr 2, 2002·International Journal of Legal Medicine·Erik EdstonJesper Johnsson
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Jun 27, 2002·Forensic Science International : Synergy·J A Ortiz-ReyL Concheiro-Carro
Aug 31, 2002·Medicine, Science, and the Law·Bing-Jie HuJia-Zhen Zhu
Mar 29, 2005·Molecular and Cellular Biochemistry·Bodh I Jugdutt, Halliday A Idikio
Mar 28, 2006·Journal of Cellular and Molecular Medicine·Genzou Takemura, Hisayoshi Fujiwara
Jul 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mark H HarpsterMark M Stayton
Jun 2, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Paul O Collinson, David C Gaze
Jun 4, 2008·The American Journal of Forensic Medicine and Pathology·Carlo P CampobassoMassimo F Colonna
Jul 14, 2010·International Journal of Legal Medicine·Tony FracassoAndreas Schmeling
Jan 22, 2013·Simulation in Healthcare : Journal of the Society for Simulation in Healthcare·Francisco M Matos, Daniel B Raemer
Jul 10, 2016·International Journal of Legal Medicine·Sara SabatassoValentin Djonov

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Citations

Jan 25, 2018·International Journal of Legal Medicine·Aleksandra AljaknaSara Sabatasso
Aug 11, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rosario Barranco, Francesco Ventura
Sep 16, 2019·Virchows Archiv : an International Journal of Pathology·Katarzyna MichaudUNKNOWN Association for European Cardiovascular Pathology (AECVP)
Feb 12, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rosario Barranco, Francesco Ventura
Dec 23, 2020·International Journal of Legal Medicine·P MarkwerthR Dettmeyer

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