PMID: 6164661Jan 1, 1981Paper

Early membrane injury in lethally irradiated salivary gland cells

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
S K El-Mofty, A J Kahn

Abstract

The early manifestations of radiation injury in salivary glands were investigated in the rat. The animals received a single X-ray dose in the range of 200-2000 rad to their neck area. Glandular changes during the first 24 hours were studied by light and electron microscopy and by measuring serum amylase activity. The amount of cell necrosis was quantitated and expressed as necrosis index (NI), Parotid NI and serum amylase activity 24 hours following irradiation were directly proportional to the X-ray dose. The submandibular gland cells were radioresistant and so were the mucous cells of the sublingual gland. The major increase in parotid acinar cell necrosis occurred between 12 and 24 hours after irradiation. However, more than 100 per cent increase in serum amylase level was detected prior to the onset of any significant cell necrosis. As early as two hours following irradiation signs of cell membrane injury were demonstrable in the parotid by electron microscopy and consisted of intracellular oedema, sequestered degenerative cell membranes, and an accumulation of intramitochondrial particles. None of these changes was detectable in the submandibular gland. The implication of membrane injury in the lethal effects of radiation ...Continue Reading

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Citations

Sep 20, 2006·Molecular and Cellular Biology·Kirsten H LimesandSteven M Anderson
Oct 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A VissinkA W Konings
Oct 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L C StephensL J Peters
Mar 13, 2015·Tissue Engineering. Part a·Andrew D ShubinDanielle S W Benoit
Dec 5, 1998·Archives of Oral Biology·R M NaglerP C Fox
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A VissinkR P Coppes
Apr 29, 2008·Brazilian Dental Journal·George BoraksRenato Paulo Chopard
Feb 15, 2002·Advances in Dental Research·A C O'Connell
Jun 7, 1986·British Medical Journal·L G Gordon, W S Lowry
Jul 17, 1982·British Medical Journal·A BarrettR L Powles
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K AbokJ Ericsson
Mar 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S K El-MoftyD J Simmons

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