Early menopause predicts angina after myocardial infarction.

Menopause : the Journal of the North American Menopause Society
Susmita ParasharViola Vaccarino

Abstract

Population studies have shown that age at menopause (AAM) predicts coronary heart disease. It is unknown, however, whether early menopause predicts post-myocardial infarction (MI) angina. We examined whether younger AAM increases risk of post-MI angina. In a prospective multicenter MI registry, 493 postmenopausal women were enrolled (mean +/- SD age, 65.4 +/- 11.3 y, and mean +/- SD AAM, 45.2 ± 7.8 y). We categorized AAM into 40 years or younger, 41 to 49 years, and 50 years or older. In the multivariable analysis, we examined whether AAM predicted 1-year post-MI angina and severity of angina after adjusting for angina before MI, demographics, comorbidities, MI severity, and quality of care (QOC). Women with early AAM (> or =40 y; n = 132, 26.8%) were younger and more often smokers but were as likely to have comorbidities as were women with an AAM of 50 years or older. Although there were no differences in pre-MI angina, MI severity, obstructive coronary disease, and QOC based on AAM, the rate of 1-year angina was higher in women with an AAM of 40 years or younger (32.4%) than in women with an AAM of 50 years or older (12.2%). In the multivariable analysis, women with an AAM of 40 years or younger had more than twice the risk o...Continue Reading

References

Mar 16, 1996·Lancet·Y T van der SchouwJ D Banga
Feb 24, 1999·Lancet·G A GreendaleE R Arriola
May 21, 1999·Archives of Internal Medicine·F B HuM J Stampfer
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Sep 1, 1999·The American Journal of Cardiology·K A MilnerH M Krumholz
Jul 2, 2002·JAMA : the Journal of the American Medical Association·Deborah GradyUNKNOWN HERS Research Group
Feb 7, 2003·Journal of the American College of Cardiology·Raymond J GibbonsUNKNOWN American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable An
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
May 7, 2004·Health and Quality of Life Outcomes·Colleen M NorrisUNKNOWN APPROACH Investigators
Mar 23, 2006·JAMA : the Journal of the American Medical Association·Harry HemingwayIlmo Keskimäki
Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Femke AtsmaYvonne T van der Schouw

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Citations

Apr 18, 2013·Menopause : the Journal of the North American Menopause Society·Maria E BleilMarcelle I Cedars
Jun 22, 2013·American Journal of Epidemiology·Ellen B GoldSiobán D Harlow
Apr 8, 2015·Climacteric : the Journal of the International Menopause Society·S S FaubionW A Rocca
Oct 4, 2011·Obstetrics and Gynecology Clinics of North America·Ellen B Gold
Dec 14, 2011·Alcoholism, Clinical and Experimental Research·Sharada D Vangipuram, William D Lyman
May 30, 2013·Menopause : the Journal of the North American Menopause Society·Maria E BleilMarcelle I Cedars
Aug 25, 2015·Maturitas·Edmond D Shenassa, Lauren M Rossen
Dec 12, 2018·Menopause : the Journal of the North American Menopause Society·Young-Taek KimMi-Ran Lee
Dec 24, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Renáta SzabóAnikó Pósa
Sep 5, 2018·BMC Complementary and Alternative Medicine·Zhiguo ZhangYanjing Chen
Oct 17, 2018·International Journal of Molecular Sciences·Swati AgarwalAsif Ahmed
Jun 26, 2021·Climacteric : the Journal of the International Menopause Society·J C StevensonN Panay

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