Early metacarpal bone mineral density loss using digital x-ray radiogrammetry and 3-tesla wrist MRI in established rheumatoid arthritis: a longitudinal one-year observational study

Arthritis
Anshul RastogiPeter C Taylor

Abstract

Objectives. Early change in rheumatoid arthritis (RA) is characterised by periarticular osteopenia. We investigated the relationship of early metacarpal digital X-ray radiogrammetry bone mineral density (DXR-BMD) change rate (RC-BMD, mg/cm(2)/month) to longitudinal changes in hand and feet radiographic and wrist MRI scores over 1 year. Materials and Methods. 10 RA patients completed the study and had wrist 3T-MRI and hand and feet X-rays at various time points over 1 year. MRI was scored by RAMRIS, X-ray was done by van der Heijde modified Sharp scoring, and RC-BMD was analysed using dxr-online. Results. There was good correlation amongst the two scorers for MRI measures and ICC for erosions: 0.984, BME: 0.943, and synovitis: 0.657. Strong relationships were observed between RC-BMD at 12-week and 1-year change in wrist marrow oedema (BME) (r = 0.78, P = 0.035) but not with erosion, synovitis, or radiographic scores. Conclusion. Early RC-BMD correlates with 1-year wrist BME change, which is a known predictor of future erosion and joint damage. However, in our pilot study, early RC-BMD did not show relationships to MRI erosion or radiographic changes over 1 year. This may reflect a slower kinetic in the appearance of MRI/radiogra...Continue Reading

References

Aug 1, 1996·Baillière's Clinical Rheumatology·K Bohndorf, J Schalm
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Mar 15, 2006·Magnetic Resonance Imaging Clinics of North America·Timothy J Mosher
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Mar 31, 2006·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Extremity Magnetic Resonance Imaging Task Force
Nov 20, 2009·Scandinavian Journal of Rheumatology·K ForslindUNKNOWN Barfot Study Group
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Methods Mentioned

BETA
X-ray
ESR

Software Mentioned

OMERACT RAMRIS

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