Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig

Physiological Reports
Rebecca M DysonIan M R Wright

Abstract

Dysfunction of the transition from fetal to neonatal circulatory systems may be a major contributor to poor outcome following preterm birth. Evidence exists in the human for both a period of low flow between 5 and 11 h and a later period of increased flow, suggesting a hypoperfusion-reperfusion cycle over the first 24 h following birth. Little is known about the regulation of peripheral blood flow during this time. The aim of this study was to conduct a comparative study between the human and guinea pig to characterize peripheral microvascular behavior during circulatory transition. Very preterm (≤28 weeks GA), preterm (29-36 weeks GA), and term (≥37 weeks GA) human neonates underwent laser Doppler analysis of skin microvascular blood flow at 6 and 24 h from birth. Guinea pig neonates were delivered prematurely (62 day GA) or at term (68-71 day GA) and laser Doppler analysis of skin microvascular blood flow was assessed every 2 h from birth. In human preterm neonates, there is a period of high microvascular flow at 24 h after birth. No period of low flow was observed at 6 h. In preterm animals, microvascular flow increased after birth, reaching a peak at 10 h postnatal age. Blood flow then steadily decreased, returning to deliv...Continue Reading

References

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Citations

Oct 4, 2016·Physiological Reports·Ian M R WrightVicki L Clifton
Sep 1, 2016·Journal of Biomedical Optics·Ryan FarraroBernard Choi
Oct 23, 2018·Clinical and Experimental Pharmacology & Physiology·Barbara E LingwoodIan M R Wright
Dec 14, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Laura A MaitozaRichard W Pierce
Mar 6, 2019·Frontiers in Physiology·Dries HendrikxGunnar Naulaers
Aug 9, 2016·Pediatric Research·Celine Corbisier de MeautsartIan M R Wright
Oct 3, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Rebecca M DysonIan M R Wright

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