Early mobilisation post-stroke: a systematic review and meta-analysis of individual participant data.

Disability and Rehabilitation
Venesha RethnamJulie Bernhardt

Abstract

To investigate the safety and efficacy of early mobilisation (EM) compared to usual care by meta-analysing individual participant data (IPD). IPD were sought from randomised controlled trials comparing out-of-bed mobilisation starting within 48 h from stroke onset to usual care for acute stroke patients. Six trials were sourced from a recent Cochrane review. Favourable outcome (modified Rankin Scale 0-2) and death at 3 months post-stroke were compared between both groups using mixed-effect logistic regression modelling. Adjusted odds ratios (aORs) with respective 95% confidence intervals (95%CI) were reported. Out of 2630 participants, 1437 (54.6%) were assigned to EM and 1193 (45.4%) to usual care. Intervention protocols varied considerably between trials. The median (interquartile range) delay to starting mobilisation post-stroke onset was 20 h (14.5-23.8) for EM and 23 h (16.7-34.3) for usual care group. Fewer EM participants had a favourable outcome at 3 months post-stroke compared to the usual care group (678 [48%] vs. 611 [52%]; aOR = 0.75, 95%CI: 0.62-0.92, p = 0.005). No difference in death at 3 months post-stroke between EM and usual care was observed (102 [7%] vs. 84 [7%]; aOR = 1.46, 95%CI: 0.92-2.31, p = 0.108). The...Continue Reading

References

Jan 5, 2008·Stroke; a Journal of Cerebral Circulation·Julie BernhardtGeoffrey Donnan
Apr 22, 2008·Scottish Medical Journal·T J QuinnM Walters
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Feb 5, 2010·Cerebrovascular Diseases·Peter LanghorneCaroline Watkins
Feb 9, 2010·BMJ : British Medical Journal·Richard D RileyGhada Abo-Zaid
Apr 16, 2013·PloS One·Thomas P A DebrayRichard David Riley
Jun 3, 2015·Cerebrovascular Diseases Extra·Simone Rosa PolettoSheila Cristina Ouriques Martins
Dec 15, 2015·Stroke; a Journal of Cerebral Circulation·Andreas R Luft, Jürg Kesselring
Mar 31, 2016·PloS One·Fanny HerissonUNKNOWN SEVEL study group
Jun 7, 2017·JAMA : the Journal of the American Medical Association·Darren B TaichmanJoyce Backus
Jul 13, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Marion F WalkerCaroline L Watkins
Jul 20, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·J M BoulangerK Butcher
Oct 30, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Julie BernhardtSteven C Cramer

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Citations

Jan 29, 2021·International nursing review·C GutenbrunnerH Catton
Jan 5, 2021·Current Opinion in Critical Care·Sabrina HernandezCarol L Hodgson
Feb 27, 2021·Frontiers in Neurology·Venesha RethnamLeonid Churilov

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