Abstract
Disruption of re-endothelialization and haemodynamic balance remains a critical side effect of drug-eluting stents (DES) for preventing intimal hyperplasia. Previously, we found that 5-aminolevulinic acid-mediated sonodynamic therapy (ALA-SDT) suppressed macrophage-mediated inflammation in atherosclerotic plaques. However, the effects on intimal hyperplasia and re-endothelialization remain unknown. In this study, 56 rabbits were randomly assigned to control, ultrasound, ALA and ALA-SDT groups, and each group was divided into two subgroups (n = 7) on day 3 after right femoral artery balloon denudation combined with a hypercholesterolemic diet. Histopathological analysis revealed that ALA-SDT enhanced macrophage apoptosis and ameliorated inflammation from day 1. ALA-SDT inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells (SMCs) and collagen but increased elastin by day 28. In vitro, ALA-SDT induced macrophage apoptosis and reduced TNF-α, IL-6 and IL-1β via the ROS-PPARγ-NF-κB signalling pathway, which indirectly inhibited human umbilical artery smooth muscle cell (HUASMC) proliferation, migration and IL-6 producti...Continue Reading
References
Jul 1, 1992·Circulation·G MontalescotD Thomas
Sep 11, 1998·Science·C Y WangA S Baldwin
Apr 25, 2000·Biochemical and Biophysical Research Communications·X WangE H Ohlstein
Jun 19, 2002·Circulation·Haim D DanenbergElazer R Edelman
Jul 31, 2002·Circulation·Haim D DanenbergGershon Golomb
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Dec 9, 2004·Current Drug Targets. Inflammation and Allergy·Raphaël GenoletLiliane Michalik
Nov 1, 2005·Experimental and Molecular Pathology·Shu LiuQixia Wu
May 26, 2006·Biochemical Pharmacology·Geoffrey GloireJacques Piette
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Neil D Perkins
Sep 30, 2010·Journal of Photochemistry and Photobiology. B, Biology·Chenghai PengWenwu Cao
Oct 12, 2010·Vascular Pharmacology·Ko-Woon ChoiSuhkneung Pyo
Sep 14, 2011·Nature Reviews. Cardiology·J Wouter JukemaPaul H A Quax
Nov 19, 2011·Journal of Interventional Cardiology·A S LotfiP Visintainer
Dec 3, 2011·Cardiovascular Research·Tomiharu NiidaFumitaka Ohsuzu
Feb 9, 2012·British Journal of Clinical Pharmacology·Inge De MeyerGuido R Y De Meyer
Oct 13, 2012·Cardiovascular Research·Maureen WanjareSharon Gerecht
Mar 5, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Xin SunYe Tian
Apr 9, 2013·Nanomedicine·Priti Nagda
Jun 12, 2013·Nature Reviews. Cardiology·Tim P van de HoefJan J Piek
Jul 16, 2014·Ultrasonics Sonochemistry·Xin SunYe Tian
Aug 15, 2014·American Journal of Physiology. Renal Physiology·David M SmallGlenda C Gobe
Oct 25, 2014·Apoptosis : an International Journal on Programmed Cell Death·Haibo ChenYe Tian
Mar 23, 2015·Ultrasound in Medicine & Biology·Juhua DanYe Tian
Jul 17, 2015·Thrombosis and Haemostasis·Z LiY Tian
Sep 30, 2015·European Heart Journal·Robert A ByrneAdnan Kastrati
Feb 26, 2016·Scientific Reports·Fang TianYe Tian
Mar 12, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Yong SunSheng-Zhong Duan
Jul 8, 2016·Advanced Materials·Xiaoqin QianYu Chen
May 4, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yu WangYe Tian
Jun 27, 2017·European Journal of Pharmacology·Yi-Qi LiDan-Li Yang
Apr 14, 2018·Journal of the American College of Cardiology·Juan TorradoLuis A Guzmán
Jun 8, 2018·Cardiovascular Research·Xin SunYe Tian