PMID: 7528767Jan 1, 1995Paper

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection

The Journal of Experimental Medicine
K P KearseA Singer

Abstract

Differentiation of immature CD4+ CD8+ thymocytes into mature CD4+ or CD8+ T cells occurs within the thymus and is dependent upon expression of antigen receptor complexes (T cell receptor [TCR]) containing clonotypic alpha/beta proteins. We have recently found that CD4+ CD8+ thymocytes express low levels of surface TCR because of limitations placed on TCR assembly by the instability of nascent TCR-alpha proteins within the endoplasmic reticulum (ER) of immature thymocytes. Because TCR-alpha/beta expression increases during development, a molecular mechanism must exist for increasing the number of assembled TCR complexes present in immature CD4+ CD8+ thymocytes that have been signaled to differentiate into mature T cells, although no such mechanism has yet been described. In the current report we have examined the molecular consequences of intracellular signals generated by engagement of surface TCR complexes on immature CD4+ CD8+ thymocytes. Isolated TCR engagement generated signals that increased TCR-alpha RNA levels and increased synthesis of TCR-alpha proteins, which, in turn, significantly increased assembly of complete TCR-alpha/beta complexes in CD4+ CD8+ thymocytes. Increased TCR-alpha protein levels in TCR-signaled CD4+ ...Continue Reading

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Citations

Oct 3, 1999·European Journal of Immunology·S ChanD Mathis
Dec 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K P KearseA Singer
Mar 2, 2005·Seminars in Immunology·Ruey-Chyi SuStephen T Smale
Apr 1, 1996·Current Opinion in Immunology·C J Guidos
Aug 1, 1996·The Journal of Experimental Medicine·W WuK P Kearse
Dec 22, 1998·The Journal of Experimental Medicine·H S AzzamP E Love
Dec 16, 1998·Immunological Reviews·D Amsen, A M Kruisbeek
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Nov 5, 2002·Annual Review of Immunology·Vanessa S Marsden, Andreas Strasser
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NaramuraH Gu
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·D AmsenA M Kruisbeek
Dec 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephan KisslerHarvey Cantor
Dec 30, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Brendan K ReedAdam G Schrum
Oct 23, 2008·PloS One·Bénédicte MugnierPierre Ferrier
Mar 25, 2015·PloS One·Sally-Anne MortlockPeter Williamson
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May 27, 2015·Pathology, Research and Practice·Jiahai ShiXiaojuan Liu
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Apr 4, 2006·Trends in Immunology·Yong-Jun Liu
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Jan 22, 2005·Journal of Leukocyte Biology·Nathalie NiederbergerNicholas R J Gascoigne

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