Early monitoring for detection of antituberculous drug-induced hepatotoxicity

The Korean Journal of Internal Medicine
Chang Min LeeOk Jae Lee

Abstract

We investigated the time of onset of antituberculous drug-induced hepatotoxicity (ADIH) and related characteristics. Adult patients (n = 1,031) treated with first-line antituberculous drugs between February 2009 and January 2013 were enrolled. Of the 1,031 patients, 108 patients (10.5%) developed ADIH a mean of 39.6 ± 43.7 days after treatment initiation. Twenty-eight patients (25.9%) developed ADIH within 7 days, 73 (67.6%) within 30 days, and the rest after 30 days. The ≤ 30-day group was characterized by higher peak alanine aminotransferase (ALT) level and a high proportion of patients with maintenance of first-line antituberculous drugs compared to the > 30-day group. In subgroup analysis, the ≤ 7-day group was characterized by higher baseline aspartate aminotransferase and ALT, high proportion of patients with maintenance of first-line antituberculous drugs, and high proportion of patients with extrapulmonary tuberculosis compared to patients with ADIH that developed beyond 7 days. In multivariate analysis, serum ALT > 40 IU/L (odds ratio [OR], 2.995; 95% confidence interval [CI], 1.580 to 5.680; p = 0.001) and presence of anti-hepatitis C virus (OR, 4.204; 95% CI, 1.822 to 9.700, p = 0.001) were independent risk factors f...Continue Reading

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Citations

Apr 9, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yu WangJian-Qing He
Jun 15, 2018·Current Opinion in Allergy and Clinical Immunology·Sowmya Nagarajan, Paul Whitaker
May 3, 2019·Journal of the Chinese Medical Association : JCMA·Tien-En ChangMing-Chih Hou
Jul 28, 2017·Tuberculosis and Respiratory Diseases·Eunyoung HeoHee Soon Chung
Sep 15, 2016·Journal of Viral Hepatitis·C TrigoL de Castro
Jul 6, 2019·Journal of the Chinese Medical Association : JCMA·Tien-En ChangMing-Chih Hou
Dec 29, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hao NiuM Isabel Lucena
Jun 2, 2021·Auto- Immunity Highlights·Yolima Puentes-OsorioDaniel Taborda

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