Early mucosal changes of the gallbladder in patients with anomalous arrangement of the pancreaticobiliary duct

Gastroenterology
K Tokiwa, N Iwai

Abstract

Anomalous arrangement of the pancreaticobiliary duct (AAPBD) is frequently associated with gallbladder cancer. The aim of this study was to characterize the early epithelial changes of the gallbladder that might be associated with carcinogenesis in patients with AAPBD. Routinely fixed tissue specimens obtained from pediatric patients with AAPBD and control patients were examined histologically with H&E, periodic acid-Schiff, and argyrophilic nucleolar organizer region (AgNOR) staining. Epithelial hyperplasia was frequently observed in the gallbladder of patients with AAPBD but not in patients without this anomaly. The incidence of epithelial hyperplasia was significantly higher in the gallbladder of patients in whom the major pancreatic duct joined the common bile duct (P-C type) than in patients in whom the common bile duct joined the pancreatic duct (C-P type). The mean AgNOR number in the gallbladder mucosa was significantly higher in patients with AAPBD than in patients without AAPBD. Patients with C-P type AAPBD had a significantly higher mean AgNOR number of the gallbladder mucosa than patients with C-P type AAPBD. Patients with AAPBD, especially those with the P-C type anomaly, have increased cellular proliferative activ...Continue Reading

Citations

Jul 28, 2011·Medicinski pregled·Nenad LalovićDanijela Batinić Skipina
Feb 16, 2010·Journal of Pediatric Surgery·Shigeru OnoNaomi Iwai
May 14, 2010·Journal of Hepato-biliary-pancreatic Sciences·Michihiro SugaiHirohumi Munakata
Nov 18, 2005·Journal of Pediatric Surgery·Shigehisa FuminoToshihisa Iwabuchi
Oct 6, 2016·Journal of Gastroenterology·Terumi KamisawaMasataka Kikuyama
Apr 30, 1999·Journal of Gastroenterology and Hepatology·S TannoY Kohgo
Mar 4, 2003·Gastrointestinal Endoscopy·Jin Kan SaiKuniaki Kojima
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Nov 1, 2005·Journal of Hepato-biliary-pancreatic Surgery·Jun KadonoTakeshi Shimizu
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Apr 10, 2003·Langenbeck's Archives of Surgery·Yoshiro MatsumotoKohichi Suda
Oct 22, 2019·Journal of Hepato-biliary-pancreatic Sciences·Kensuke YoshimotoYoshinori Igarashi

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