Early nasal high-flow versus Venturi mask oxygen therapy after lung resection: a randomized trial

Critical Care : the Official Journal of the Critical Care Forum
Mariano Alberto PennisiMassimo Antonelli

Abstract

Data on high-flow nasal oxygen after thoracic surgery are limited and confined to the comparison with low-flow oxygen. Different from low-flow oxygen, Venturi masks provide higher gas flow at a predetermined fraction of inspired oxygen (FiO2). We conducted a randomized trial to determine whether preemptive high-flow nasal oxygen reduces the incidence of postoperative hypoxemia after lung resection, as compared to Venturi mask oxygen therapy. In this single-center, randomized trial conducted in a teaching hospital in Italy, consecutive adult patients undergoing thoracotomic lung resection, who were not on long-term oxygen therapy, were randomly assigned to receive high-flow nasal or Venturi mask oxygen after extubation continuously for two postoperative days. The primary outcome was the incidence of postoperative hypoxemia (i.e., ratio of the partial pressure of arterial oxygen to FiO2 (PaO2/FiO2) lower than 300 mmHg) within four postoperative days. Between September 2015 and April 2018, 96 patients were enrolled; 95 patients were analyzed (47 in high-flow group and 48 in Venturi mask group). In both groups, 38 patients (81% in the high-flow group and 79% in the Venturi mask group) developed postoperative hypoxemia, with an unad...Continue Reading

References

May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·I AuriantF Parquin
Dec 29, 2004·Annals of Surgery·Philip P GoodneyJohn D Birkmeyer
Oct 15, 2005·American Journal of Respiratory and Critical Care Medicine·Miquel FerrerAntoni Torres
Nov 14, 2006·Chest·Stavros G MemtsoudisSelwyn O Rogers
Jan 30, 2007·Respiratory Medicine·Christophe PerrinJérôme Mouroux
Sep 25, 2007·The Annals of Thoracic Surgery·Naveed AlamDavid Amar
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Daniel J BoffaCameron D Wright
Oct 15, 2008·Intensive Care Medicine·Aurélie LefebvreAntoine Rabbat
Sep 29, 2011·Intensive Care Medicine·Benjamin SztrymfJean-Damien Ricard
Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin
Jan 22, 2014·Intensive Care Medicine·Samir Jaber, Massimo Antonelli
Jul 9, 2014·American Journal of Respiratory and Critical Care Medicine·Salvatore Maurizio MaggioreMassimo Antonelli
Apr 18, 2015·Journal of Applied Physiology·Winfried MöllerStanislav Tatkov
May 20, 2015·JAMA : the Journal of the American Medical Association·François StéphanUNKNOWN BiPOP Study Group
May 20, 2015·The New England Journal of Medicine·Jean-Pierre FratUNKNOWN REVA Network
Mar 13, 2016·Intensive Care Medicine·Laurent PapazianElie Azoulay
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Gonzalo HernándezRafael Fernández
Nov 20, 2016·Journal of Applied Physiology·Winfried MöllerGeorg Nilius
Dec 21, 2016·American Journal of Respiratory and Critical Care Medicine·Tommaso MauriAntonio Pesenti
Mar 23, 2017·Critical Care : the Official Journal of the Critical Care Forum·Gonzalo HernándezLaura Colinas
May 11, 2018·Critical Care : the Official Journal of the Critical Care Forum·Tommaso MauriGiacomo Grasselli
Dec 14, 2018·Current Opinion in Anaesthesiology·Jakob WittensteinMarcelo Gama de Abreu
Jan 11, 2019·The Lancet. Respiratory Medicine·Salvatore Maurizio MaggioreFlavia Petrini

❮ Previous
Next ❯

Citations

Jan 4, 2019·American Journal of Respiratory and Critical Care Medicine·Athanasios Chalkias, Theodoros Xanthos
Jan 4, 2019·American Journal of Respiratory and Critical Care Medicine·Domenico L GriecoJean-Christophe M Richard
Apr 2, 2020·Critical Care : the Official Journal of the Critical Care Forum·Emanuele GilardiMariano Alberto Pennisi
Jan 17, 2021·Anaesthesia Critical Care & Pain Medicine·Pascal BernaMarc Garnier
May 31, 2017·The Cochrane Database of Systematic Reviews·Amanda CorleyAndrew F Smith
Mar 5, 2021·The Cochrane Database of Systematic Reviews·Sharon R LewisAndrew F Smith
Sep 3, 2021·Pneumologie·Jens GottliebThomas Fühner

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT02544477
NCT02107183

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.