Early nasogastric tube feeding in optimising treatment for hyperemesis gravidarum: the MOTHER randomised controlled trial (Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding)

BMC Pregnancy and Childbirth
Iris J GrootenRebecca C Painter

Abstract

Hyperemesis gravidarum (HG), or intractable vomiting during pregnancy, is the single most frequent cause of hospital admission in early pregnancy. HG has a major impact on maternal quality of life and has repeatedly been associated with poor pregnancy outcome such as low birth weight. Currently, women with HG are admitted to hospital for intravenous fluid replacement, without receiving specific nutritional attention. Nasogastric tube feeding is sometimes used as last resort treatment. At present no randomised trials on dietary or rehydration interventions have been performed. Small observational studies indicate that enteral tube feeding may have the ability to effectively treat dehydration and malnutrition and alleviate nausea and vomiting symptoms. We aim to evaluate the effectiveness of early enteral tube feeding in addition to standard care on nausea and vomiting symptoms and pregnancy outcomes in HG patients. The MOTHER trial is a multicentre open label randomised controlled trial ( www.studies-obsgyn.nl/mother ). Women ≥ 18 years hospitalised for HG between 5 + 0 and 19 + 6 weeks gestation are eligible for participation. After informed consent participants are randomly allocated to standard care with intravenous rehydrati...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Feb 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R M GulleyJ M Gulley
Sep 1, 1996·Obstetrics and Gynecology·J J HsuC H Kim
Feb 24, 2001·The Australian & New Zealand Journal of Obstetrics & Gynaecology·C SmithJ Dandeaux
Sep 6, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C B PearceH D Duncan
May 16, 2002·American Journal of Obstetrics and Gynecology·Gideon KorenAdrienne Einarson
May 16, 2002·American Journal of Obstetrics and Gynecology·Laura A MageeGordon H Guyatt
Jul 9, 2002·Obstetrics and Gynecology·Julie A GazmararianAdele L Franks
Jul 12, 2005·Human Reproduction Update·M F G VerbergJ G Grudzinskas
Sep 10, 2005·American Journal of Obstetrics and Gynecology·Jennifer L Bailit
Jan 2, 2008·American Journal of Obstetrics and Gynecology·Calla HolmgrenMichael Varner
May 13, 2008·Health and Quality of Life Outcomes·Anaïs Lacasse, Anick Bérard
May 22, 2008·European Journal of Epidemiology·Irene SandvenKjetil K Melby
Aug 30, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·A LacasseA Bérard
Aug 4, 2009·International Journal of Nursing Studies·Zoe PowerHeather Waterman
Jul 17, 2010·BMC Medicine·J K JueckstockI Mylonas
Oct 15, 2010·The New England Journal of Medicine·Jennifer R Niebyl
Jul 14, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·M V E VeenendaalT J Roseboom
Jan 13, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Guro StokkeJone Trovik

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Citations

May 23, 2016·Autonomic Neuroscience : Basic & Clinical·Martha BustosSteve Caritis
Feb 28, 2020·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Kimber Wakefield MacGibbon
Aug 20, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Gideon Koren, Rana Cohen
Dec 24, 2018·BMC Pregnancy and Childbirth·E SahinI I Muderris
Oct 13, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M H KootR C Painter
May 26, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Kelly NijstenRebecca C Painter
Sep 17, 2021·Nutrition Research Reviews·Kate Maslin, Caitlin Dean

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Methods Mentioned

BETA
biopsies

Software Mentioned

MOTHER
CONSORT

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