Early neonatal and postweaning social emotional deprivation interferes with the maturation of serotonergic and tyrosine hydroxylase-immunoreactive afferent fiber systems in the rodent nucleus accumbens, hippocampus and amygdala

Neuroscience
Tomasz GosK Braun

Abstract

The impact of early emotional experience on the development of serotonergic and dopaminergic fiber innervation of the nucleus accumbens, hippocampal formation and the amygdala was quantitatively investigated in the precocious rodent Octodon degus. Two animal groups were compared: 1) degus which were repeatedly separated from their parents during the first three postnatal weeks, after weaning they were individually reared in chronic social isolation and 2) controls which were reared undisturbed with their families. In the deprived animals 5-hydroxytryptamine-immunoreactive fiber densities were increased in the core region of the nucleus accumbens (up to 126%), in the central nucleus of the amygdala (up to 112%) and in the outer subregion of the dentate gyrus stratum moleculare (up to 149%), whereas decreased fiber densities were detected in the dentate subgranular layer (down to 86%) and in the stratum lacunosum of the hippocampal cornu ammonis region 1 (down to 86%). Tyrosine hydroxylase-immunoreactive fiber densities were increased in the core (up to 115%) and shell region (up to 113%) of the nucleus accumbens of deprived animals, whereas decreased fiber densities (down to 84%) were observed in the hilus of the dentate gyrus. ...Continue Reading

References

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Citations

Oct 22, 2008·Molecular Neurobiology·Cynthia L BetheaJudy L Cameron
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Tomasz GosBernhard Bogerts
Jan 9, 2013·Behavioural Brain Research·Shabana Yusufishaq, J Amiel Rosenkranz
Dec 19, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas Adams, J Amiel Rosenkranz
Jun 10, 2008·Journal of Affective Disorders·Tomasz GosBernhard Bogerts
Jun 29, 2010·Behavioural Brain Research·Andreas Abraham, Michael Gruss
Jan 16, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L SchipperG van Dijk
Dec 29, 2020·Brain, Behavior, and Immunity·Li-Heng TuanLi-Jen Lee

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