Jun 13, 1998

Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns

Burns : Journal of the International Society for Burn Injuries
A EldadHannah Ben-Bassat

Abstract

Chemical burns are slow healing injuries and their depth is difficult to assess. Tissue destruction continues as long as active material is present in the wound site. The routine therapy for treatment of full thickness chemical burns is early excision; it shortens hospitalization and reduces morbidity. However, presently there is no specific treatment for chemical burns of partial thickness. This study examined several treatment modalities for partial thickness chemical burns: surgical excision; laser ablation and chemical debridement with Debridase or trypsin-linked to gauze. Chemical burns were inflicted with nitrogen mustard (NM -- a nitrogen analog to sulfur mustard -- mustard gas) in an experimental guinea pig model. Debridase was most effective and reduced significantly lesion area of burns after 'humid' exposure to 2 mg NM. The healing action of Debridase was also evident in the significantly higher histopathological score of biopsies from local tissue obtained on day 5. Laser ablation was most effective and accelerated healing of burn lesions after 'dry' exposure to 5 mg NM. The histopathology score of the laser treated burns was higher on day 4 compared to untreated controls. It is concluded that for partial thickness ...Continue Reading

  • References13
  • Citations27

References

  • References13
  • Citations27

Citations

Mentioned in this Paper

Chemical Burns
Nitromin brand of mechlorethamine oxide
Laser Coagulation
Antineoplastic Agents, Alkylating
Administration, Topical
Microbicides, Topical
Wound Healing
Debridement
Trypure
Burn Injury

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