Abstract
The occurrence of drug intolerance (DI) after an acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) is an important reason for quitting treatment. Nevertheless, the association between DI and major cardiac and cerebrovascular events (MACCE) is poorly reported in the literature, therefore, we analysed potential relationship between DI and MACCE (a composite of ACS, PCI, heart failure, and stroke) during follow-up. From 1 January 2014 to 31 December 2015, 891 consecutive patients after ACS or coronary revascularization were referred to cardiac rehabilitation (CR) programme and included in a dedicated registry where DI was analysed and treatment appropriately tailored. Three hundred and nine patients (34.7%) developed DI, 26.9% of them were female. Angiotensin-converting enzyme (ACE) inhibitors and statins were the most frequent drugs which caused DI, followed by beta-blockers and calcium channel blockers, in 13.1%, 12.8%, 7.5%, and 5.5% of patients, respectively. During a median follow-up of 18 (interquartile range 11-24) months after CR, MACCE occurred in 14.1% of patients with DI and 8.1% without DI (P = 0.007). At multivariable model, DI to 1 drug [odds ratio (OR) 1.8, 95% confidence interval (CI) 1.01-3...Continue Reading
References
Aug 2, 2001·Circulation·G R DagenaisUNKNOWN HOPE Investigators
Apr 20, 2002·Lancet·UNKNOWN IONA Study Group
Nov 12, 2003·The New England Journal of Medicine·Marc A PfefferUNKNOWN Valsartan in Acute Myocardial Infarction Trial Investigators
Aug 1, 2006·Journal of the American College of Cardiology·Christopher P CannonEugene Braunwald
Dec 13, 2006·Circulation·Amir KashaniHarlan M Krumholz
Jan 11, 2007·JAMA : the Journal of the American Medical Association·Jeppe N RasmussenDavid A Alter
Jan 29, 2010·European Heart Journal·Maarten L Simoons, Stephan Windecker
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Vittorio MaioJoshua J Gagne
Sep 3, 2013·European Heart Journal·UNKNOWN Task Force MembersJose Luis Zamorano
Dec 3, 2013·European Journal of Clinical Investigation·Nathan ArtomAldo Pende
May 6, 2014·Journal of Clinical Lipidology·John R Guyton The National Lipid Association Statin Intolerance Panel
Jul 26, 2014·European Journal of Preventive Cardiology·Nana PogosovaUNKNOWN Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation of the European S
Jan 15, 2015·European Journal of Internal Medicine·Baris GencerFrançois Mach
Jan 15, 2015·European Heart Journal·Tomas JernbergMagnus Janzon
Feb 20, 2015·European Heart Journal·Erik S StroesUNKNOWN European Atherosclerosis Society Consensus Panel
Mar 11, 2015·JAMA : the Journal of the American Medical Association·Connie B Newman, Jonathan A Tobert
Mar 15, 2015·Heart & Lung : the Journal of Critical Care·Han-Yang ChenRobert J Goldberg
Apr 11, 2015·Archives of Medical Science : AMS·Maciej BanachDimitri P Mikhailidis
Apr 25, 2015·Expert Opinion on Drug Safety·Maciej BanachDimitri P Mikhailidis
Sep 1, 2015·European Heart Journal·Marco RoffiUNKNOWN ESC Scientific Document Group
Jan 19, 2016·Current Opinion in Lipidology·Ulrich LaufsWinfried März
Aug 16, 2016·British Journal of Clinical Pharmacology·Seyed Hamidreza MahmoudpourUNKNOWN PREDICTION-ADR consortium
Mar 18, 2017·Journal of the American College of Cardiology·Maria-Corina SerbanRobert S Rosenson
Mar 21, 2017·Journal of Cardiovascular Medicine·Patrizia MarasCatherine Klersy
Sep 10, 2017·European Heart Journal·Borja IbanezUNKNOWN ESC Scientific Document Group
Citations
Nov 8, 2018·European Heart Journal·Christian Schmied
Mar 17, 2020·European Heart Journal. Cardiovascular Pharmacotherapy
Jul 13, 2019·European Heart Journal. Cardiovascular Pharmacotherapy·Heinz DrexelStefan Agewall
Oct 9, 2018·European Heart Journal. Cardiovascular Pharmacotherapy·Raul D Santos
Jan 8, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Jelena ČelutkienėOvidiu Chioncel
Oct 19, 2021·Frontiers in Cardiovascular Medicine·Han ChenJunbo Ge