Early-Onset HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Pathogens
Alvaro SchwalbEduardo Gotuzzo

Abstract

Vertical transmission of HTLV-1 could lead to the early development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This significantly affects quality of life and increases morbimortality. To describe the epidemiological and clinical characteristics of patients with early-onset HAM/TSP, defined as disease onset before 20 years of age. This is a retrospective study from an HTLV-1 clinical cohort between 1989 and 2019. We searched for medical records of patients with (1) diagnosis of HTLV-1 infection using two ELISA and/or one Western blot, (2) clinical diagnosis of HAM/TSP by neurological assessment, and (3) HAM/TSP symptom-onset before 20 years of age. A total of 38 cases were identified in the cohort; 25 were female (66%). The median age of onset was 14 years old. 31 (82%) cases had HTLV-1 testing done among family members; 22 out of 25 tested mothers (88%) were HTLV-1 positive. Most patients (27/34) were breastfed for more than one year. Disease progression measured through EDSS and IPEC-1 showed an upward trend towards worsening spasticity with 18 patients (47%) eventually requiring mobility aids. Cases of early-onset HAM/TSP are not of rare occurrence, which translates into many more years of depende...Continue Reading

References

Feb 15, 1989·International Journal of Cancer. Journal International Du Cancer·E L MurphyW A Blattner
Nov 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·A KataokaT Tsuda
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S HinoT Miyamoto
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·K J JefferyC R Bangham
Jul 4, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·C Sanchez-PalaciosY Maldonado
Jun 15, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jorge O AlarcónGerald V Quinnan
Oct 28, 2006·AIDS Research and Human Retroviruses·Carlos M De Castro-CostaGraham P Taylor
Nov 15, 2006·Archives of Neurology·Stéphane OlindoDidier Smadja
Nov 18, 2006·Lancet Neurology·Abelardo Q C Araujo, Marcus Tulius T Silva
Dec 16, 2006·Jornal de pediatria·Achiléa Lisboa BittencourtMaria Fátima Paim de Oliveira
Dec 15, 2007·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Eduardo GotuzzoSten H Vermund
Feb 21, 2009·Revista Do Instituto De Medicina Tropical De São Paulo·Nadia Carmela Santos QuispeAdele Caterino-de-Araujo
Jul 7, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J PrimoA L Bittencourt
Dec 25, 2010·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Paula Silva ChampsJoão Gabriel Ramos Ribas
Jul 23, 2011·International Journal of Cancer. Journal International Du Cancer·Shiro UenoAkihiko Okayama
Jul 26, 2011·International Journal of Dermatology·Masahiro AmanoFrancisco A Kerdel
Feb 11, 2012·Arquivos de neuro-psiquiatria·José Vicente Pereira MartinsAbelardo de Queiroz Campos Araújo
Nov 20, 2012·Frontiers in Microbiology·Antoine Gessain, Olivier Cassar
Aug 13, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·José Lucas Sena da SilvaAchiléa L Bittencourt
Nov 19, 2013·PLoS Neglected Tropical Diseases·Renata OkajimaJose Antonio Sanches
May 8, 2014·PloS One·Satoshi NozumaHiroshi Takashima
Oct 24, 2014·Expert Review of Clinical Immunology·Fabiola MartinSteven Jacobson
Jan 1, 2015·Nature Reviews. Disease Primers·Charles R M BanghamGraham P Taylor
May 22, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Susana Otero-RomeroXavier Montalban
Nov 15, 2016·Frontiers in Microbiology·Carolina AlvarezKristien Verdonck
Jun 19, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cinthya Maria Neves VarandasAchiléa L Bittencourt
Mar 18, 2019·The Lancet Child & Adolescent Health·Andrew J PrendergastPhilippe Van de Perre
May 28, 2019·Frontiers in Microbiology·Carolina Rosadas, Graham P Taylor
Jun 12, 2019·Tropical Medicine & International Health : TM & IH·Emiliana Eusebio-PonceEduardo Anguita

❮ Previous
Next ❯

Citations

Aug 29, 2021·Pathogens·Chloé Journo, Fabiola Martin

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assays

Software Mentioned

Stata SE
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.