Early onset of cisplatin-induced nephrotoxicity in streptozotocin-diabetic rats treated with insulin

Basic & Clinical Pharmacology & Toxicology
R Sarangarajan, W Cacini

Abstract

Mechanism of protection against cisplatin nephrotoxicity in streptozotocin-diabetic rats is unclear but is associated with decreased renal platinum accumulation. This study was designed to determine whether normalization of hyperglycaemia by insulin treatment to six week streptozotocin-diabetic rats reversed protection against cisplatin nephrotoxicity. Male Sprague-Dawley rats divided into 3 groups (n=10/group) (1) non-diabetic (2) untreated streptozotocin-diabetic and (3) insulin-treated streptozotocin-diabetic groups were rendered diabetic using streptozotocin (65 mg/kg body weight, intravenous). At the end of 6 weeks, Group 3 animals were treated with insulin (subcutaneously) for 21 days to normalize glucose. After 21 days of insulin treatment, the mean +/- S.D. plasma glucose (mg%) in Group 3 animals at 144.8 +/- 22.03, was significantly lower than Group 2 animals (412 +/- 24.69) and comparable to age-matched non-diabetic (Group 1) animals. Blood urea nitrogen at 24 hr after intraperitoneal administration of cisplatin (5 mg/kg body weight) increased by a factor 2.5 in Group 3 compared to 1.1 and 1.3 in Group 1 and Group 2 animals respectively. In the same animals, at 96 hr the blood area nitrogen increased by a factor of 3....Continue Reading

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Citations

Feb 11, 2015·Chemico-biological Interactions·Marcia C da Silva FariaAntonio Cardozo Dos Santos
Aug 19, 2007·The American Journal of the Medical Sciences·Xin YaoKenneth Nugent
Apr 25, 2019·Journal of Cellular Physiology·Habibeh Mashayekhi-SardooAmirhossein Sahebkar

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