PMID: 11337194May 5, 2001Paper

Early onset of glutamatergic and GABAergic synaptic activity in the visual layers of the rodent superior colliculus

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
René JüttnerT Rothe

Abstract

During postnatal development, the retinocollicular pathway undergoes activity-dependent refinement, resulting in the precise retinotopic map seen in adults. Previous studies established that retinal efferents reach the mouse superior colliculus (SC) by embryonic day 16. Morphologically, synapses were found in the rat SC before birth. As part of an extended project aimed at understanding the development of synaptic transmission in the visual layers of the SC, we report here the presence of functionally active synapses immediately after birth. Circuit activity in mouse SC neurons was detected in horizontal slices of the visual layers using cell-attached voltage clamp. The spontaneous discharge of action potentials was abolished by glutamatergic blockers and facilitated by bicuculline, showing that circuit activity is based on synaptic transmission and that the action of gamma-aminobutyric acid is inhibitory. Using whole-cell voltage clamp, spontaneous glutamatergic postsynaptic currents as well as miniature GABAergic postsynaptic currents were recorded on postnatal day 1. Excitatory and inhibitory postsynaptic currents could also be evoked by electrical stimulation. Glutamatergic postsynaptic currents comprised both (S)-alpha-ami...Continue Reading

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Citations

Mar 19, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yoshiyuki SakataShoji Nakamura
May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R Schliebs
Mar 24, 2006·The European Journal of Neuroscience·Yoshiyuki SakataShoji Nakamura
Jun 3, 2010·Developmental Neurobiology·Brigitte van ZundertMartha Constantine-Paton
Nov 11, 2005·Progress in Neurobiology·Christine L Torborg, Marla B Feller

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