Early onset of hypertension and serum electrolyte changes as potential predictive factors of activity in advanced HCC patients treated with sorafenib: results from a retrospective analysis of the HCC-AVR group

Oncotarget
Andrea Casadei GardiniGiovanni Luca Frassineti

Abstract

Hypertension (HTN) is frequently associated with the use of angiogenesis inhibitors targeting the vascular endothelial growth factor pathway and appears to be a generalized effect of this class of agent. We investigated the phenomenon in 61 patients with advanced hepatocellular carcinoma (HCC) receiving sorafenib. Blood pressure and plasma electrolytes were measured on days 1 and 15 of the treatment. Patients with sorafenib-induced HTN had a better outcome than those without HTN (disease control rate: 63.4% vs. 17.2% (p=0.001); progression-free survival 6.0 months (95% CI 3.2-10.1) vs. 2.5 months (95% CI 1.9-2.6) (p<0.001) and overall survival 14.6 months (95% CI9.7-19.0) vs. 3.9 months (95% CI 3.1-8.7) (p=0.003). Sodium levels were generally higher on day 15 than at baseline (+2.38, p<0.0001) in the group of responders (+4.95, p <0.0001) compared to patients who progressed (PD) (+0.28, p=0.607). In contrast, potassium was lower on day 14 (-0.30, p=0.0008) in the responder group (-0.58, p=0.003) than in those with progressive disease (-0.06, p=0.500). The early onset of hypertension is associated with improved clinical outcome in HCC patients treated with sorafenib. Our data are suggestive of an activation of the renin-angioten...Continue Reading

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Citations

Dec 13, 2019·Expert Review of Cardiovascular Therapy·Matteo SantoniRodolfo Montironi
Jan 8, 2020·Expert Review of Anticancer Therapy·Casadei-Gardini AndreaErcolani Giorgio
Oct 3, 2018·World Journal of Gastroenterology : WJG·Giorgia MarisiAndrea Casadei Gardini
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Dec 4, 2020·Critical Reviews in Oncology/hematology·Eleonora LaiMario Scartozzi
Feb 16, 2021·Frontiers in Oncology·Clelia DonisiMario Scartozzi
Jun 3, 2021·Cancers·Giovanni MarascoOn Behalf Of The Italian Liver Cancer Ita Li Ca Group
Jul 13, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Ilario Giovanni RapposelliAndrea Casadei-Gardini

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