PMID: 11912383Mar 26, 2002Paper

Early onset prostate cancer: predictors of clinical grade

The Journal of Urology
Sandra V KotsisKathleen A Cooney

Abstract

Prostate cancer is typically a disease of elderly men and, therefore, it has not been well characterized in those affected at a young age. With the advent of serum prostate specific antigen testing, we are able to detect prostate cancer in young men even in the absence of symptoms. We studied a large group of early onset prostate cancer cases to illustrate the clinical presentation of men with early onset prostate cancer and to determine the effect of family history on Gleason grade as a reflection of prognosis. All study participants were enrolled in the University of Michigan Prostate Cancer Genetics Project. Enrollment criterion of the Prostate Cancer Genetics Project includes a diagnosis of prostate cancer at age 55 years or younger. Descriptive statistics and logistic regression were used to characterize early onset prostate cancer and assess the associated prognostic factors. The study group was comprised of 257 men with prostate cancer diagnosed at age 55 years or younger. Median age at diagnosis was 51 years (range 34 to 55) and almost half of the participants reported a negative family history of prostate cancer. In logistic regression analysis having an affected father, an affected first-degree relative or an affected...Continue Reading

References

Mar 1, 1992·Human Pathology·D F Gleason
Jan 1, 1972·Journal of Surgical Oncology·D E JohnsonA G Ayala
Jun 1, 1983·British Journal of Urology·G S Harrison
Jun 1, 1994·British Journal of Urology·A RanaR A Elton
Nov 20, 1997·The Journal of Urology·P A KupelianJ H Suh
Sep 28, 1998·JAMA : the Journal of the American Medical Association·P C AlbertsenM J Barry

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Citations

Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·E SpanglerT R Rebbeck
Mar 11, 2011·PloS One·Jacqueline M MajorMichael W Kattan
May 7, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K-C HuangT A Bismar
Jan 18, 2007·BJU International·Matthew R HotstonRajendra A Persad
Nov 4, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Wade J SextonPatricia Troncoso
Jul 24, 2004·Urologic Oncology·Jeffrey B MarotteJoseph C Presti
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Feb 10, 2004·The Journal of Urology·Hongyan WuDouglas Soderdahl
Apr 16, 2003·Clinical Genetics·A M NiederH Ostrer

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