Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells

Journal of Clinical and Experimental Hematopathology : JCEH
Yasumasa SugitaChiaki Nakaseko

Abstract

Severe acute lung injury is a rare but life-threatening complication associated with bortezomib. We report a patient with multiple myeloma who developed a severe diffuse alveolar hemorrhage (DAH) immediately after the first bortezomib administration. The patient was suspected to have pulmonary involvement of myeloma, which caused DAH after rapidly eradicating myeloma cells in the lungs with bortezomib. Rechallenge with bortezomib was performed without recurrent DAH. In patients with multiple myeloma who manifest abnormal pulmonary shadow, we should be aware of early-onset severe DAH after bortezomib administration, which might be due to pulmonary involvement of myeloma cells.

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Citations

May 22, 2019·Clinical Case Reports·Atsuki FurubeNoboru Takayanagi
Jan 1, 2019·Case Reports in Medicine·Prakash KharelAjay Dhakal
Dec 30, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Eda AyparGülsan Türköz-Sucak
Aug 6, 2020·Respiratory Medicine Case Reports·Ingrid M Wirth, Gregory E Peters

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