PMID: 8965651Mar 1, 1996Paper

Early ontogeny of catecholaminergic cell lineage in brain and peripheral neurons monitored by tyrosine hydroxylase-lacZ transgene

Brain Research. Molecular Brain Research
J H SonT H Joh

Abstract

As the first and rate limiting enzyme in the biosynthetic pathway for catecholamine (CA) neurotransmitters, tyrosine hydroxylase (TH) is a specific phenotypic marker for CA cells in the central and peripheral nervous systems of adult animals. During embryogenesis, TH expression appears permanently within cells destined to be CA-secreting during adult life, and transiently in several cell types that will not express TH in adulthood. In this study, we examined the early ontogeny of TH expression in transgenic mouse embryos by following the expression of a lacZ reporter, driven by the tissue-specific promoter of the rat TH gene. The lacZ reporter product, beta-galactosidase (beta-gal), visualized by X-gal staining, first became apparent in primordia of sensory ganglia serving the glossopharyngeal (IX) and vagal (X) cranial nerves at embryonic day (E)9.0. Between E9.5 and E10.5, beta-gal expression extended to the remaining cranial sensory ganglia serving the trigeminal (V) and facial (VII) nerves, dorsal root ganglia, ventrolateral neural tube and sympathetic ganglion primordia. During that same period, the first beta-gal expression in the embryonic brain also appeared within distinct regions, such as the ventral prosencephalon, t...Continue Reading

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P CochardI B Black
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Aug 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Seiger, L Olson
Aug 1, 1973·Developmental Biology·G S Golden
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Apr 1, 1983·The American Journal of Anatomy·A D'Amico-Martel, D M Noden

❮ Previous
Next ❯

Citations

Mar 1, 2003·Frontiers in Neuroendocrinology·Sara Wells, David Murphy
May 15, 2004·American Journal of Veterinary Research·Peter J DickinsonRichard A LeCouteur
May 16, 2002·Experimental Neurology·Eric K RichfieldHoward J Federoff
Apr 14, 2010·Molecular and Cellular Endocrinology·Eva SzarekPaul Thomas
Jun 24, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Faustino MarínLuis Puelles
Feb 24, 2012·Journal of Neurochemistry·Tim Aumann, Mal Horne
Jan 17, 2002·The Journal of Comparative Neurology·Tania VitalisOlivier Cases
May 14, 1998·The Journal of Comparative Neurology·L Puelles, C Verney
Apr 15, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·B B Johnson
Nov 30, 2018·Frontiers in Neuroanatomy·Claudia M García-PeñaAlfredo Varela-Echavarría
Nov 6, 2020·Cellular and Molecular Life Sciences : CMLS·María Figueres-OñateLaura López-Mascaraque

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.