Abstract
As the first and rate limiting enzyme in the biosynthetic pathway for catecholamine (CA) neurotransmitters, tyrosine hydroxylase (TH) is a specific phenotypic marker for CA cells in the central and peripheral nervous systems of adult animals. During embryogenesis, TH expression appears permanently within cells destined to be CA-secreting during adult life, and transiently in several cell types that will not express TH in adulthood. In this study, we examined the early ontogeny of TH expression in transgenic mouse embryos by following the expression of a lacZ reporter, driven by the tissue-specific promoter of the rat TH gene. The lacZ reporter product, beta-galactosidase (beta-gal), visualized by X-gal staining, first became apparent in primordia of sensory ganglia serving the glossopharyngeal (IX) and vagal (X) cranial nerves at embryonic day (E)9.0. Between E9.5 and E10.5, beta-gal expression extended to the remaining cranial sensory ganglia serving the trigeminal (V) and facial (VII) nerves, dorsal root ganglia, ventrolateral neural tube and sympathetic ganglion primordia. During that same period, the first beta-gal expression in the embryonic brain also appeared within distinct regions, such as the ventral prosencephalon, t...Continue Reading
References
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P CochardI B Black
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Jan 1, 1991·Neuron·E J Hess, M C Wilson
Nov 1, 1991·Neuron·E H MercerR D Palmiter
Nov 1, 1991·Neuron·R P KapurR D Palmiter
Nov 15, 1991·Biological Psychiatry·J F Greden
Feb 1, 1990·Developmental Biology·D M Katz, M J Erb
Oct 1, 1990·Developmental Biology·G BaetgeM D Gershon
Sep 21, 1990·Cell·P H Patterson
Mar 1, 1989·Neuron·U ErnsbergerH Rohrer
Jul 1, 1989·Neuron·D J Anderson
Mar 1, 1985·Developmental Biology·G M JonakaitI B Black
Mar 28, 1986·Science·N M Le Douarin
Mar 15, 1973·Brain Research·A Björklund, A Nobin
Aug 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Seiger, L Olson
Aug 1, 1973·Developmental Biology·G S Golden
Jun 20, 1981·The Journal of Comparative Neurology·L A SpechtD J Reis
Jun 20, 1981·The Journal of Comparative Neurology·L A SpechtD J Reis
Sep 1, 1981·Developmental Biology·G TeitelmanD J Reis
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Jan 1, 1982·Neuroscience·B BergerA Prochiantz
Jan 20, 1983·Nature·J Price, A W Mudge
May 1, 1983·Developmental Biology·C F DreyfusI B Black
Jan 1, 1984·Developmental Biology·G M JonakaitI B Black
Apr 1, 1983·The American Journal of Anatomy·A D'Amico-Martel, D M Noden
Jun 1, 1993·Trends in Neurosciences·J M Lauder
Apr 13, 1995·Nature·Q Y ZhouR D Palmiter
Dec 1, 1994·Brain Research. Molecular Brain Research·N MinJ H Son
Jul 1, 1994·Brain Research. Molecular Brain Research·S O HuhJ H Son
Dec 1, 1994·Neuron·J M Verdi, D J Anderson
Jan 1, 1993·Neuroscience·H Baker, A I Farbman
Citations
Oct 12, 2005·Journal of Neurocytology·Hayato SasakiHarriet Baker
Mar 1, 2003·Frontiers in Neuroendocrinology·Sara Wells, David Murphy
Jan 21, 2000·Brain Research. Molecular Brain Research·J J SchimmelD M Chikaraishi
Feb 17, 2005·Molecular and Cellular Biology·Hélène KieferJacques Mallet
Aug 16, 2006·Neuro-degenerative Diseases·Lyutha MaskriHermann Lübbert
May 15, 2004·American Journal of Veterinary Research·Peter J DickinsonRichard A LeCouteur
Feb 2, 2002·Experimental Neurology·Hong S ChunJin H Son
May 16, 2002·Experimental Neurology·Eric K RichfieldHoward J Federoff
Oct 9, 2015·Pain·Pablo R Brumovsky
Apr 14, 2010·Molecular and Cellular Endocrinology·Eva SzarekPaul Thomas
Jun 24, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Faustino MarínLuis Puelles
May 20, 2003·Journal of Neurochemistry·Tomiyasu MurataNorio Kaneda
Feb 24, 2012·Journal of Neurochemistry·Tim Aumann, Mal Horne
Jun 20, 1997·Brain Research·V K PabbathiL W Haynes
Jan 17, 2002·The Journal of Comparative Neurology·Tania VitalisOlivier Cases
Feb 10, 1998·The Journal of Comparative Neurology·J M LuqueJ G Nicholls
May 14, 1998·The Journal of Comparative Neurology·L Puelles, C Verney
Sep 28, 2005·Neurochemical Research·Anna J ReynoldsIan A Hendry
Apr 15, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·B B Johnson
Nov 30, 2018·Frontiers in Neuroanatomy·Claudia M García-PeñaAlfredo Varela-Echavarría
Jun 26, 2001·Oncogene·A LeoneK Kelly
Nov 6, 2020·Cellular and Molecular Life Sciences : CMLS·María Figueres-OñateLaura López-Mascaraque
Feb 9, 2020·Journal of Neuroscience Methods·David GodefroyYoussef Anouar
Sep 1, 2006·Development·Takashi MoriguchiJames Douglas Engel