Early opacification of silicone intraocular lenses: Laboratory analyses of 6 explants

Journal of Cataract and Refractive Surgery
Liliana WernerR J Olson

Abstract

To report laboratory analyses of 6 intraocular lenses (IOLs) explanted from patients who had visual disturbances caused by early postoperative opacification of the lens optic. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Six patients with 3-piece silicone lenses presented with optic cloudiness as early as a few hours after implantation. The lenses were implanted in 4 locations in Brazil and in France. The lenses in Brazil were stored at the same location before implantation. Gross and microscopic analyses were performed (dry and hydrated states). One half of each specimen underwent gas chromatography/mass spectrometry (GC/MS) analysis and/or extraction by isopropyl alcohol or acetonitrile. One lens also underwent scanning electron microscopy (SEM) with energy dispersive x-ray spectroscopy (EDS). The IOLs were examined for the presence of contaminants or deposits that could cause fast optic opacification. The IOLs showed a white optic discoloration in the hydrated state but became transparent on complete dehydration. Suspect exogenous chemical compounds were identified in GC/MS analyses; general classes included terpenes and ketones, typically found in industrial cleaning agents and fumigants. Surface...Continue Reading

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Oct 12, 2004·Journal of Cataract and Refractive Surgery·Christiana Rebello HilgertLiliana Werner
Mar 28, 2006·Journal of Cataract and Refractive Surgery·Liliana WernerX Michael Liu
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Citations

Feb 14, 2012·American Journal of Ophthalmology·Anish DhitalLiliana Werner
Nov 15, 2011·Journal of Cataract and Refractive Surgery·Choul Yong Park, Roy S Chuck
Apr 3, 2007·Journal of Cataract and Refractive Surgery·Liliana Werner
Feb 6, 2007·Journal of Cataract and Refractive Surgery·Mostafa ElgoharyNisar Ahmed
Jul 27, 2010·Journal of Cataract and Refractive Surgery·Liliana Werner
Aug 28, 2015·Vestnik oftalmologii·A A GamidovV I Siplivyy
Aug 8, 2019·European Journal of Ophthalmology·Nick StanojcicDavid Ps O'Brart
Jan 21, 2021·Ophthalmic Surgery, Lasers & Imaging Retina·F Hakan OnerLiliana Werner
Jul 21, 2021·Journal of Cataract and Refractive Surgery·Nicole R FramDon Pham

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