Early or late fresh frozen plasma administration in newborns and small infants undergoing cardiac surgery: the APPEAR randomized trial

British Journal of Anaesthesia
P BianchiSurgical and Clinical Outcome REsearch (SCORE) group

Abstract

In newborns and small infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) and blood priming, it is unclear whether there is reduced blood loss if fresh frozen plasma (FFP) is added to the CPB priming volume. This single-centre, randomized trial tested the hypothesis that the administration of FFP after CPB (late FFP group) is superior to FFP priming (early FFP group) in terms of postoperative bleeding and overall red blood cell (RBC) transfusion. Seventy-three infants weighing <10 kg were randomly allocated to receive FFP to supplement RBCs in the CPB priming solution ( n =36) or immediately after CPB ( n =37). The primary endpoint was a difference in postoperative blood loss; secondary endpoints included the amount of RBCs and FFP transfused through the first 48 postoperative hours. All patients were included in the analysis. Patients in the late FFP arm had greater postoperative mean blood loss than patients in the early FFP arm [33.1 ( sd 20.6) vs 24.1 (12.9) ml kg -1 ; P =0.028], but no differences in transfusions were found. The subgroup of cyanotic heart disease patients had comparable results, but with greater use of RBCs in the late FFP group. In infants undergoing cardiac surgery, FFP in the priming so...Continue Reading

References

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Aug 10, 2013·Journal of Thrombosis and Haemostasis : JTH·C AttardV Ignjatovic

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Citations

Aug 17, 2018·Journal of Thrombosis and Haemostasis : JTH·M RanucciE Baryshnikova
May 1, 2020·General Thoracic and Cardiovascular Surgery·Takahiro TamuraKimitoshi Nishiwaki
Feb 6, 2018·Seminars in Cardiothoracic and Vascular Anesthesia·Richard J Ing, Mark D Twite
Jun 20, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Jared Roberts, Daniel Tolpin

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