Early orchiopexy improves subsequent testicular development and spermatogenesis in the experimental cryptorchid rat model

The Journal of Urology
Kentaro MizunoKenjiro Kohri

Abstract

The most appropriate period for orchiopexy is controversial. We performed histological analyses of undescended testes to evaluate the influence of orchiopexy timing in an experimental cryptorchid rat model. Furthermore, we extrapolated the timing of orchiopexy in humans from our results. Experimental cryptorchid rats were induced with androgen blocker by injecting flutamide into the abdomen of pregnant Sprague-Dawley rats (Chubu Kagaku Shizai, Nagoya, Japan) for 7 days from days 14 to 20 of gestation. Approximately 90% of male newborns had undescended testes and we performed orchiopexy on them 4, 5 and 7 weeks after birth. The testes were removed 10 weeks after birth in all groups, and weight and histological findings were assessed. A modified Johnsen score was used to determine spermatogenesis maturity and germ cell apoptosis was also evaluated. Nonoperated undescended testes showed atrophic and hypospermatogenesis with germ cell apoptosis, whereas treated undescended testes showed the development of early elongated spermatids. In addition, performing orchiopexy 4 weeks after birth decreased the degeneration of undescended testes compared with that in other groups. From the point of view of only testicular development 4-week-o...Continue Reading

References

Jun 1, 1976·Fertility and Sterility·L I Lipshultz
Aug 11, 1991·Endocrinology·J R SpencerJ Imperato-McGinley
Aug 1, 1990·The Journal of Urology·S J KoganS B Levitt
Aug 1, 1989·The Journal of Urology·D S HuffM A Keating
Feb 1, 1984·The Journal of Urology·E GaudioF Carpino
Jun 1, 1995·British Journal of Urology·P A LeeR E LaPorte
Apr 1, 1995·The Journal of Urology·I M McAleerG F Billman
Jun 7, 2002·The Journal of Urology·Hiroshi TomomasaHiromichi Ishikawa
Nov 25, 2003·The Journal of Urology·Julia Spencer Barthold, Ricardo González
Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Kentaro MizunoKenjiro Kohri

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Citations

May 30, 2014·Pediatric Surgery International·Reju J Thomas, Andrew J A Holland
Jan 24, 2012·The Journal of Urology·Hideyuki KamisawaKenjiro Kohri
Apr 20, 2010·The Journal of Urology·Hideyuki KamisawaYuraro Hayashi
Jul 11, 2009·Urology·Yoshiyuki KojimaYutaro Hayashi
Jul 19, 2011·Urology·Sun-Ouck KimSoo Bang-Ryu
Oct 31, 2012·Urology·Jenny H YieeUNKNOWN Urologic Diseases in America Project
Sep 10, 2013·The Journal of Urology·Ugur UyeturkAdnan Gucuk
Jan 28, 2021·International Journal of Experimental Pathology·Ana P Ferragut CardosoMerielen G Nascimento E Pontes

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