Early Pathogenesis of Wesselsbron Disease in Pregnant Ewes

Pathogens
Judith OymansJeroen Kortekaas

Abstract

Wesselsbron virus (WSLV) is a neglected, mosquito-borne flavivirus that is endemic to the African continent. The virus is teratogenic to ruminants and causes a self-limiting febrile illness in humans. Wesselsbron disease manifests with similar clinical signs and occurs in the same areas under the same climatic conditions as Rift Valley fever, which is therefore included in the differential diagnosis. Although the gross pathology of WSLV infection in pregnant ewes is reported in literature, the pathogenesis that leads to stillbirths, congenital malformations and abortion has remained undescribed. In the present study, pregnant ewes were inoculated with WSLV and subjected to detailed clinical- and histopathology 8 days later. The virus was mainly detected in foetal trophoblasts of the placenta and in neural progenitor cells, differentiated neurons, oligodendrocytes, microglia and astrocytes. Our study demonstrates that WSLV efficiently crosses the maternal-foetal interface and is highly neuroinvasive in the ovine foetus.

References

May 12, 1998·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·E Z MushiM Raborokgwe
Aug 26, 2006·Nature Clinical Practice. Neurology·Roberta L Debiasi, Kenneth L Tyler
Dec 27, 2007·The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses·B L Johnston, J M Conly
Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Mar 12, 2013·Vector Borne and Zoonotic Diseases·Jacqueline WeyerJanusz T Paweska
Apr 1, 2016·Clinical Microbiology Reviews·Didier Musso, Duane J Gubler
Oct 17, 2017·Advances in Virus Research·Kerstin Wernike, Martin Beer
Nov 18, 2017·FEMS Microbiology Letters·Jan C Semenza, Jonathan E Suk
Jun 8, 2018·Archives of Virology·Milene Rocha RibeiroMaurício Lacerda Nogueira
Dec 15, 2018·Antiviral Research·Ute ZieglerMartin H Groschup
Aug 28, 2019·Virulence·Brooke LiangIndira U Mysorekar
Jan 22, 2020·PLoS Neglected Tropical Diseases·Judith OymansJeroen Kortekaas

Citations

Apr 3, 2021·PLoS Neglected Tropical Diseases·Heiko D GuggemosSandra Junglen

Datasets Mentioned

BETA
JN226796.1

Methods Mentioned

BETA
PCR

Related Concepts

Congenital Abnormality
Astrocytes
Differential Diagnosis
Fetus
Flavivirus
Literature
Culicidae
Neurons
Oligodendroglia
Placenta

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Bulletin - Office International Des épizooties
W O Neitz
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
C S HEYMANNB DE MEILLON
Bulletin de la Société de pathologie exotique et de ses filiales
P Brès
© 2021 Meta ULC. All rights reserved