Early pattern of epilepsy in the ring chromosome 20 syndrome

Epilepsia
D VilleC Chiron

Abstract

The characteristics of epilepsy in ring chromosome 20 have been reported in adolescents and adults. The mode of onset most often remains imprecise. To clarify this onset period, we studied the early-onset features in our personal series and in the reported pediatric cases. Our series comprises one child with an onset of epilepsy in the neonatal period and five others with an onset before age 8 years. The cases in the literature with an epilepsy onset before 8 years also were reviewed. Seizures in the neonatal period were described as motor seizures. Our personal patient with a neonatal onset had severe psychomotor delay. In both infancy and early childhood, the EEG showed no interictal frontal localization of the anomalies, and no long-lasting seizure was recorded. Seizures with terror and hallucinations usually appeared from about age 4 years. It is not before the age of 8 years that the usual interictal EEG pattern appeared of rhythmic theta slow-waves activity with spikes predominating in frontal areas described in adolescence and adulthood. The interictal EEG showed 1- to 2-Hz delta slow waves and spike-and-waves predominating in frontal areas, but no physiologic activity. In ring 20 chromosome, specific epilepsy features a...Continue Reading

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Citations

Aug 23, 2011·Journal of Autism and Developmental Disorders·Maximilian GahrPaul Plener
Oct 14, 2010·BMC Medical Genetics·Daniela GiardinoLidia Larizza
May 5, 2010·Italian Journal of Pediatrics·Giovanni Sorge, Anna Sorge
Aug 24, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pietro AvanziniStefano Meletti
Nov 26, 2010·Expert Review of Neurotherapeutics·Dimitrios I TsiptsiosMichail A Koutroumanidis
May 7, 2009·Developmental Medicine and Child Neurology·Dorothée VilleVincent DES Portes
Aug 7, 2007·American Journal of Medical Genetics. Part a·Angela F Davies, Caroline Mackie Ogilvie
Mar 25, 2016·Epilepsia·Maria Freire de MouraFrancis Renault
Mar 13, 2012·European Journal of Medical Genetics·Robert D DaberNancy B Spinner
Oct 18, 2011·Pediatric Neurology·Silvia CappaneraNelia Zamponi
Oct 18, 2011·Seizure : the Journal of the British Epilepsy Association·Ashalatha RadhakrishnanKurupath Radhakrishnan
Feb 22, 2012·European Journal of Medical Genetics·Grace J NohJohn M Graham
Nov 7, 2016·Epilepsy Research·Aglaia VignoliMaria Paola Canevini
Nov 29, 2012·Clinical EEG and Neuroscience·F Irsel TezerSerap Saygi
Dec 29, 2020·Frontiers in Neurology·Angela PeronMaria Paola Canevini
Jul 10, 2020·Seizure : the Journal of the British Epilepsy Association·A P HamadR M F Fernandes

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