PMID: 8583139Nov 1, 1995Paper

Early perivenular fibrogenesis--precirrhotic lesions among moderate alcohol consumers and chronic alcoholics

Journal of Hepatology
V T SavolainenP J Karhunen

Abstract

Cirrhosis is believed to be preceded by "precirrhotic" lesions indicating initial fibrogenesis in the perivenular area. We investigated three previously described markers of early perivenular fibrogenesis: the thickness of the rim of the terminal hepatic venule, perivenular fibrosis and perivenular fibronectin deposition. The frequencies of these features were evaluated and compared to long-term daily alcohol intake in autopsy series of 120 males comprising abstainers, moderate alcohol consumers and chronic heavy alcohol consumers. Thickening of the rim of the terminal hepatic venule showed no correlation to the long-term daily ethanol intake. In contrast, compared to abstainers, daily alcohol intake between 40 and 80 g for an average of 25 years was associated in an increased number of subjects with perivenular fibrosis (13.3% vs 38.9%, p < 0.05), and with perivenular fibronectin deposition (13.3% vs 44.4%, p < 0.025). Similarly, daily intake exceeding 80 g was associated in an increased number of subjects with perivenular fibrosis (56.1%, p < 0.001) and with perivenular fibronectin deposition (56.1%, p < 0.001). A daily intake exceeding 80 g (110 g/d vs 240 g/d) did not, however, further increase the occurrence of these lesio...Continue Reading

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Citations

Jan 1, 1997·Journal of Hepatology·V T SavolainenP J Karhunen
Oct 1, 1996·International Journal of Andrology·J PajarinenP J Karhunen
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·V T SavolainenP J Karhunen
Dec 6, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ki M MakNancy M Hoo
Dec 25, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert S O'SheaUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Jul 5, 2016·Clinics in Liver Disease·Ryan E Childers, Joseph Ahn
Jul 5, 2016·Clinics in Liver Disease·Kristina Rachel Chacko, John Reinus
Feb 25, 2003·Toxicologic Pathology·Qin Su, Peter Bannasch
Jul 8, 2011·Digestive Diseases·F ScaglioniS Bellentani
Nov 12, 2009·The American Journal of Gastroenterology·Robert S O'SheaArthur J McCullough
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aparna VenkatramanVictor M Darley-Usmar
Jan 18, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jesse RomanDavid Guidot
Jan 28, 2005·European Journal of Gastroenterology & Hepatology·Loreta A KondiliBashkim Resuli
Oct 4, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ki M Mak, C Y Maximilian Png

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