Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?

European Journal of Clinical Pharmacology
Kristin MoksnesO Dale

Abstract

We have investigated the arterio-venous difference in the pharmacokinetics of 50 microg fentanyl during the first hour following nasal administration and documented its tolerability in opioid-naïve middle-aged to elderly patients. Twelve male patients (range in age 47-84 years) scheduled for transurethral resection of the prostate gland received a 100-microl dose of 50 microg fentanyl base as a fentanyl citrate formulation in one nostril. Simultaneous arterial and venous blood samples for analyses of fentanyl were drawn at baseline and at 1, 3, 5, 7, 9, 13, 15, 20, 25, 35, 45 and 60 min after drug administration. Vital signs, sedation and symptoms of local irritation were recorded. The arterial C(max) (maximum serum concentration) of 0.83 ng/ml was nearly twofold higher than the venous C(max) of 0.47 ng/ml, and the arterial T(max) (time to maximum serum concentration) of 7.0 min was about 5 min shorter than the venous T(max) of 11.6 min. The arterial AUC(0-60) (area under the curve from 0 to 60 min after administration) of 21 min*ng/ml was approximately 30% larger than the venous AUC(0-60) of 15 min*ng/ml (all p values < or = 0.005). Venous T(max) and C(max) did not predict the corresponding arterial values. No significant adve...Continue Reading

References

Aug 1, 1991·Anesthesiology·J B StreisandT H Stanley
Jan 1, 1987·The Journal of Pharmacology and Experimental Therapeutics·J C Scott, D R Stanski
May 26, 1999·Clinical Pharmacology and Therapeutics·D J HermannK T Muir
Jan 19, 2000·European Journal of Clinical Pharmacology·S K GuthrieE F Domino
Sep 15, 2001·Clinical Pharmacology and Therapeutics·K M RentschK Fattinger
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·O DaleE D Kharasch
Nov 12, 2002·Clinical Pharmacology and Therapeutics·Ola DaleEvan D Kharasch
Jan 30, 2004·Internal Medicine Journal·P GlareK Clark
Oct 13, 2006·The Journal of Pharmacy and Pharmacology·Ola DalePer G Djupesland
Jun 1, 1993·Der Schmerz·H W StriebelA Rieger

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Citations

Aug 21, 2012·Journal of Pharmacokinetics and Pharmacodynamics·Richard N UptonLars Popper
Oct 27, 2012·Clinical Pharmacokinetics·Jörn LötschGerd Geisslinger
Mar 31, 2009·European Journal of Clinical Pharmacology·Luciana de Barros DuarteSérgio Pereira da Cunha
Jul 22, 2010·Expert Review of Anticancer Therapy·Irene Panagiotou, Kyriaki Mystakidou
May 26, 2011·Expert Opinion on Pharmacotherapy·Kyriaki MystakidouAthanasios Gouliamos
May 6, 2009·Expert Opinion on Drug Delivery·Peter Watts, Alan Smith
Oct 2, 2012·Current Medical Research and Opinion·Nicholas MooreHélène Schneid
Mar 5, 2010·Current Medical Research and Opinion·Debby VissersJeroen Jansen
Jul 6, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Matthew G KestenbaumJ Cameron Muir
Feb 14, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pietro FagiolinoRosa Eiraldi
Jan 30, 2010·Clinical Therapeutics·Nicole M L Veldhorst-JanssenMarco A E Marcus
Jan 21, 2012·Acta Anaesthesiologica Scandinavica·M S HansenJ B Dahl
Nov 26, 2013·Annals of Emergency Medicine·Anders P KarlsenMorten S Hansen
May 7, 2015·Acta Anaesthesiologica Scandinavica·G P KuritaO Dale
Apr 3, 2012·Pharmacology & Therapeutics·Stanislas Grassin-DelylePhilippe Devillier
Sep 8, 2010·Pain·Nora M Hagelberg, Klaus T Olkkola
Dec 15, 2010·Thérapie·Philippe DevillierCharles Advenier
Sep 15, 2016·The Journal of Pharmacology and Experimental Therapeutics·Phillip A SacconePeter J H Scott
Nov 9, 2016·Annals of Emergency Medicine·Daniel S TszePeter S Dayan
Mar 13, 2015·Palliative Medicine·Olav Magnus S FredheimPetter C Borchgrevink
Nov 18, 2009·European Journal of Anaesthesiology·Sarah J CapperGuy L Ludbrook
Jul 21, 2010·British Journal of Clinical Pharmacology·Baba S MohammedJames S McLay
Jul 3, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Ola Dale
Mar 17, 2016·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Adrian P MurphyRonan O'Sullivan
Apr 28, 2010·Expert Review of Neurotherapeutics·Mellar P Davis
Mar 25, 2017·Drugs·Stephan A Schug, Sonya Ting
Oct 13, 2019·The Journal of Pharmacology and Experimental Therapeutics·Weize Huang, Nina Isoherranen
Aug 26, 2018·European Journal of Clinical Pharmacology·Ida TylleskarOla Dale
Apr 4, 2021·European Journal of Clinical Pharmacology·Aymen A Al-QurainMichael D Wiese

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