Early-Phase Vascular Healing of Bioabsorbable vs. Durable Polymer-Coated Everolimus-Eluting Stents in Patients With ST-Elevation Myocardial Infarction - 2-Week and 4-Month Analyses With Optical Coherence Tomography

Circulation Journal : Official Journal of the Japanese Circulation Society
Masahiro ShimodaTetsuya Amano

Abstract

Despite the revolution of coronary stents, there remain concerns about the risk of stent thrombosis, especially in patients with ST-elevation myocardial infarction (STEMI). The present study compared early vascular healing as a contributing factor to reducing stent thrombosis between Xience everolimus-eluting stents (X-EES) and Synergy everolimus-eluting stents (S-EES) in patients with STEMI. Methods and Results: The present study included 47 patients with STEMI requiring primary percutaneous coronary intervention with X-EES (n=25) or S-EES (n=22). Optical coherence tomography (OCT) assessments of the stented lesions were performed 2 weeks and 4 months after stent implantation. Neointimal strut coverage, malapposition and the frequency of thrombus formation were evaluated. In the 2-week OCT analysis, the proportion of covered struts in S-EES (42.4±15.4%) was significantly higher than in X-EES (26.3±10.1%, P<0.001). In the 4-month OCT analysis, the proportion of covered struts in S-EES (72.2±17.9%) was still significantly higher than in X-EES (62.0±14.9%, P=0.04). Compared with X-EES, S-EES showed a higher proportion of covered struts in the early phase after stent implantation for STEMI patients.

References

Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Jun 13, 2006·The American Journal of Cardiology·Teruyoshi KumeKiyoshi Yoshida
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Feb 14, 2007·The New England Journal of Medicine·Gregg W StoneMartin B Leon
May 10, 2007·JAMA : the Journal of the American Medical Association·Htut K WinUNKNOWN EVENT Registry Investigators
Jul 31, 2007·Journal of the American College of Cardiology·Lisette Okkels JensenLeif Thuesen
May 28, 2009·Annals of Biomedical Engineering·Juan M Jiménez, Peter F Davies
Jun 23, 2009·JACC. Cardiovascular Interventions·Neville KukrejaUNKNOWN Interventional Cardiologists of the Thoraxcenter (2000 to 2005)
Jul 22, 2009·American Heart Journal·Nieves GonzaloEvelyn Regar
Nov 21, 2009·JACC. Cardiovascular Interventions·Hiram G BezerraDaniel I Simon
Jan 6, 2011·Circulation. Cardiovascular Interventions·Gaku NakazawaRenu Virmani
Jan 7, 2011·Current Pharmaceutical Design·Marc VorpahlRenu Virmani
Mar 17, 2012·Journal of the American College of Cardiology·Guillermo J TearneyUNKNOWN International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT)
Apr 7, 2012·Journal of the American College of Cardiology·Konstantinos C KoskinasGeorge D Giannoglou
Jun 22, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gregory J WilsonKeith D Dawkins
Aug 1, 2013·Circulation. Cardiovascular Interventions·Michael J EppihimerJuan F Granada
Jul 20, 2017·Circulation·Tom AdriaenssensUNKNOWN Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.