PMID: 8606398Mar 1, 1996Paper

Early plasma amino acid pool alterations in patients with military gunshot/missile wounds

The Journal of Trauma
G ZunićJ Taseski

Abstract

Plasma amino acid profiles in patients during the early period (first 18 hours) following military gunshot/missile wounds were investigated. Patients (n = 29) were casualties from the war in the former Yugoslavia with injury severity scores ranging from 4 to 18. They were divided into three groups: soft tissue (muscle) damage, wounds with fractures, and vital structures injured. Controls were normal blood donors (n = 17). Free amino acids were analyzed in venous plasma. Increased concentrations of phenylalanine and glutamine associated with increased molar phenylalanine/tyrosine ratio in plasma indicated increased net protein catabolism in the peripheral tissues, regardless of the type of injured tissues. Decreased plasma arginine, ornithine and citrulline levels, accompanied with increased molar glutamine/valine ratio, suggested disturbance in urea cycle activity, although urea level was not altered. We concluded that early changes in plasma amino acid pool characteristics after wounds were of systemic origin, not related to the type of injured tissues.

References

Aug 1, 1977·The American Journal of Clinical Nutrition·R W Wannemacher
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Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·A Barbul
Sep 1, 1971·The American Journal of Physiology·S A Adibi
Nov 1, 1983·Burns, Including Thermal Injury·X J ChangT S Shih
Jun 1, 1991·Amino Acids·A Briddon, V G Oberholzer

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Citations

May 31, 2001·International Journal of Environmental Health Research·F R Al-NeamyA Bener
Jan 24, 2004·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Gordana Zunić
Mar 17, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·Y GundersenP K Opstad
Mar 10, 2001·The American Journal of Clinical Nutrition·P KlassenN W Solomons

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