Early pneumonia and timing of antibiotic therapy in patients after nontraumatic out-of-hospital cardiac arrest

Critical Care : the Official Journal of the Critical Care Forum
Kristian HellenkampRolf Wachter

Abstract

While early pneumonia is common in patients after out-of-hospital cardiac arrest (OHCA), little is known about the impact of pneumonia and the optimal timing of antibiotic therapy after OHCA. We conducted a 5-year retrospective cohort study, including patients who suffered from OHCA and were treated with therapeutic hypothermia. ICU treatment was strictly standardized with defined treatment goals and procedures. Medical records, chest radiographic images and microbiological findings were reviewed. Within the study period, 442 patients were admitted to our medical ICU after successfully resuscitated cardiac arrest. Of those, 174 patients fulfilled all inclusion and no exclusion criteria and were included into final analysis. Pneumonia within the first week could be confirmed in 39 patients (22.4%) and was confirmed or probable in 100 patients (57.5%), without a difference between survivors and non-survivors (37.8% vs. 23.1% confirmed pneumonia, p = 0.125). In patients with confirmed pneumonia a tracheotomy was performed more frequently (28.2 vs. 12.6%, p = 0.026) compared to patients without confirmed pneumonia. Importantly, patients with confirmed pneumonia had a longer ICU- (14.0 [8.5-20.0] vs. 8.0 [5.0-14.0] days, p < 0.001) ...Continue Reading

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Citations

Nov 7, 2019·The New England Journal of Medicine·Bruno FrançoisUNKNOWN CRICS-TRIGGERSEP Network and the ANTHARTIC Study Group
Feb 14, 2020·Internal and Emergency Medicine·Sharri Junadi MortensenMichael Noel Cocchi
Oct 2, 2020·Journal of the American College of Emergency Physicians Open·Michael Sonnier, Jon C Rittenberger
Oct 30, 2020·Circulation·Christopher B FordyceUNKNOWN American Heart Association Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Cou
Apr 21, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Rana K LatifJiapeng Huang
Jul 25, 2021·Journal of Clinical Medicine·Gregor S ZimmermannHubert Hautmann

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