Early postischemic 45Ca accumulation in rat dentate hilus

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
H Benveniste, N H Diemer

Abstract

Several studies have found postischemic regional accumulation of calcium to be time-dependent and coincident with the progression of ischemic cell change. In the most vulnerable cells in the hippocampus one would therefore expect to find a primary and specific early uptake of calcium after ischemia. Autoradiograms of 45Ca and 3H-inulin distribution were investigated before and 1 h after 20 min ischemia in the rat hippocampus. Two different methodological approaches were used for administration of 45Ca: (a) administration via microdialysis probes, (b) intraventricular injection. During control conditions the 45Ca autoradiograms showed variations in distribution volume in accordance with 3H-inulin determination of extracellular space size. One hour after ischemia a massive accumulation of 45Ca was found in the dentate hilus. No change in the distribution pattern of 3H-inulin could be demonstrated 1 h after ischemia. We suggest that 45Ca accumulation in dentate hilus 1 h after ischemia is a result of increased Ca2+ uptake before irreversible cell damage occurs and is not due to passive influx of calcium across a leaky plasma membrane.

References

May 1, 1979·Stroke; a Journal of Cerebral Circulation·W A Pulsinelli, J B Brierley
Jul 1, 1977·Laboratory Investigation; a Journal of Technical Methods and Pathology·M BorgersW A Jacob
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R K WongA I Basbaum
Feb 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·P Astrup
Jan 1, 1983·The Journal of Physiology·G L CollingridgeH McLennan
Feb 1, 1980·Annals of Neurology·P A Schwartzkroin, A R Wyler
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö
Jan 1, 1983·Annals of Neurology·M E Raichle
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R P SimonB S Meldrum
Oct 1, 1984·Journal of Neurochemistry·G A Dienel
Mar 1, 1983·Stroke; a Journal of Cerebral Circulation·A Ames, F B Nesbett
Sep 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K A HossmannL Csiba
Jan 1, 1981·Neurochemical Research·J Toth, A Lajtha
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
May 1, 1981·Neuropathology and Applied Neurobiology·N H Diemer, E Siemkowicz

Citations

Aug 1, 1994·Hippocampus·P S Buckmaster, P A Schwartzkroin
Jan 1, 1995·Journal of Neuroscience Methods·P L Bonate
Jun 1, 1995·Journal of Neuroscience Methods·G C NewmanC S Patlak
Jan 1, 1990·Progress in Neurobiology·H Benveniste, P C Hüttemeier
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund
Jan 1, 1989·Acta histochemica·J HessN H Diemer
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·James A Bourne
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·N J DunU Förstermann
Aug 6, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Alberto Battezzati, Simona Bertoli
Jul 1, 1993·The Journal of Pharmacy and Pharmacology·T ArakiK Kogure
Jun 1, 1990·Molecular and Chemical Neuropathology·T ArakiM Murakami
Nov 25, 1997·Annals of the New York Academy of Sciences·R C LinJ A Connor
Jun 5, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peter J HutchinsonJ D Pickard
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LiuF R Sharp
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Bernabeu, F R Sharp
Apr 26, 2003·The European Journal of Neuroscience·Shozo JinnoToshio Kosaka
Jan 1, 1995·Advances in Neuroimmunology·M A DeCoster
Jun 1, 1989·Journal of Neurochemistry·H Benveniste
Nov 1, 1989·Acta Neurologica Scandinavica·T ArakiK Izumiyama
May 16, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·T GeeraertsB Vigué
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·M Aschner, J L Aschner
Jun 1, 1993·Journal of Hepatology·K KuritaH Shimazu
Feb 13, 2001·Methods : a Companion to Methods in Enzymology·S H Khan, A Shuaib
Mar 4, 1996·The Journal of Comparative Neurology·P S BuckmasterP A Schwartzkroin
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I A Silver, M Erecińska
Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C M PiconeJ Dedman
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H PoignetR Massingham
Jun 8, 2002·Physiological Measurement·P J HutchinsonJ D Pickard

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