Early postnatal development of the immune system in piglets: the redistribution of T lymphocyte subsets

Cellular Immunology
H StepanovaM Faldyna

Abstract

In this study, we have characterised postnatal changes in T lymphocyte subsets, especially gammadelta T lymphocytes, in blood, spleen and lymph nodes. Detection was carried out using two-colour flow cytometry and three-colour immunohistochemistry. During ontogeny, there was a significant increase in the total percentage of gammadelta T cells in the spleen and blood. In the lymph nodes, there were no age-dependent changes in the total percentage of gammadelta T cells, but the percentage of the gammadeltaTCR+CD8+ subpopulation significantly increased. The tissue distribution of gammadeltaTCR+CD8+ and gammadeltaTCR+CD8- cells in the lymph nodes is random and not collocated with a particular area of the organ. Furthermore, postnatal development was characterised by an increasing frequency of CD8+CD3+CD4-gammadeltaTCR-, which was compensated by a decreasing proportion of CD4+ lymphocytes. Double positive CD4+CD8+ lymphocytes were rare during the first month of life and a significant age-dependent increase of these cells was found in all the compartments monitored.

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Citations

Jan 5, 2014·Developmental and Comparative Immunology·Benoît LevastHenri Salmon
Apr 17, 2014·Toxicology and Applied Pharmacology·Małgorzata Pomorska-MólZygmunt Pejsak
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Jan 1, 2014·Research in Veterinary Science·In Su CheonCheol-Heui Yun
Jan 29, 2013·Developmental and Comparative Immunology·Stephanie C TalkerWilhelm Gerner
May 20, 2011·Veterinary Immunology and Immunopathology·Hana StepanovaMartin Faldyna
Feb 11, 2012·Cytokine·Hana StepanovaMartin Faldyna
May 16, 2020·Journal of Immunology Research·Małgorzata Pomorska-MólJan Włodarek
Jul 6, 2018·Parasites & Vectors·Barbara FreudenschussAnja Joachim
Jul 2, 2021·Veterinary Research·Evelien BiebautDominiek Maes

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