Early postnatal development of wakefulness-sleep cycle and neuronal responsiveness: a multiunit activity study on freely moving newborn rat

Electroencephalography and Clinical Neurophysiology
V TamásyK Lissák

Abstract

The development of the wakefulness-sleep cycle and neuronal responsiveness was studied on freely moving 1-, 3-, 5- and 7-day-old rats. Semimicroelectrodes were implanted under ether anaesthesia for multiunit activity (MUA) recording from the mesencephalic reticular formation (MRF) and basal forebrain area (FB). Following recovery from surgery and between the recording sessions pups were put back to the nest to be fed by their mothers. In a temperature-controlled environment continous MUA records were made between 16:00-18:00 and 19:00-21:00 h. In the MRF and FB the MUA was high during wakefulness, it decreased to a stable low level in quiet sleep and appeared to reach the highest values in paradoxical sleep. Neurone populations in the MRF and FB responded to somatosensory (air puffs), visual (flicker) and acoustic (1100 Hz) stimulation by a significant increase of MUA from the first day of life. In the MRF the rate of responsiveness increased during the first postnatal week; however, MUA responses to different stimuli exhibited different developmental time-courses. A high rate of responsiveness to each stimulus was characteristic of FB units. This neonatal 'supersensitivity' tended to decrease with age and the time-course of de...Continue Reading

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Citations

Dec 16, 2004·Behavioral Neuroscience·Mark S BlumbergEric D Johnson
Apr 14, 2005·PLoS Biology·Karl A E KarlssonMark S Blumberg
Mar 29, 2014·Developmental Neurobiology·Greta SokoloffMark S Blumberg
Mar 4, 2005·Journal of Sleep Research·Mark S BlumbergEthan J Mohns
Mar 4, 2005·Journal of Sleep Research·Marcos G Frank, H Craig Heller
Apr 14, 2015·Developmental Psychobiology·Mark S BlumbergCarlos Del Rio-Bermudez
Aug 7, 2008·Current Biology : CB·Ravi Allada, Jerome M Siegel
Aug 6, 2009·Nature Reviews. Neuroscience·Jerome M Siegel

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