Early postnatal stress alters place conditioning to both mu- and kappa-opioid agonists

The Journal of Pharmacology and Experimental Therapeutics
Clifford C Michaels, Stephen G Holtzman

Abstract

Clinical literature has established a link between early childhood incidents of neglect and trauma and adult problems with substance abuse. In rats, such early life stress has been modeled using a maternal separation (MS) paradigm in which rat pups were removed from their mothers for a few hours daily during the first two postnatal weeks. In this study, we used the MS model to investigate the effects of early postnatal stress on place conditioning to both mu- and kappa-opioid agonists in male and female Long-Evans rats. Offspring of both rearing conditions [MS or nonhandled (NH)] were conditioned using a biased procedure to saline, the mu-opioid agonist morphine (3.0, 5.6, and 10 mg/kg s.c.), or the kappa-opioid agonist spiradoline (0.3, 1.0, and 3.0 mg/kg) for 3 days, followed by a drug-free place-conditioning test 24 h later. Saline was administered in the morning, 30 min before confinement in one compartment, whereas morphine or spiradoline was administered in a similar manner 6 h later in the opposite compartment. MS offspring spent significantly more time in the morphine-paired compartment than NH offspring, indicating a greater place preference for the mu-opioid agonist. In the case of spiradoline, NH offspring spent sign...Continue Reading

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Citations

Apr 23, 2013·Psychopharmacology·Rachel I AndersonElena I Varlinskaya
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jaclyn M SchwarzStaci D Bilbo
Oct 18, 2011·Cellular and Molecular Life Sciences : CMLS·H A TejedaR Henriksson
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Oct 2, 2009·Peptides·Richard J Bodnar

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