Early Postnatal Stress Impairs Cognitive Functions of Male Rats Persisting Until Adulthood

Frontiers in Behavioral Neuroscience
A HolubováR Šlamberová

Abstract

Methamphetamine (MA) is the most abused "hard" illicit drug in the Czech Republic. Drugs abused during pregnancy are not hazardous merely to the mother, but also to developing fetuses. The offspring of drug-addicted mothers are also often exposed to perinatal stressors that may impair brain development of affected progeny. The present study examines the effect of perinatal stressors and drug exposure on cognitive function in male progeny. In the present study, rat mothers were divided into three groups according to drug treatment during pregnancy: controls (C); saline (SA, s.c., 1 ml/kg); MA (s.c., 5 mg/ml/kg). Litters were divided into two groups according to postnatal stressors: non-stressed controls (N); Maternal separation (MS). For evaluation of learning and memory, adult male progeny were tested in the Morris Water Maze (MWM). Our results revealed no significant effects caused by prenatal drug or prenatal stress exposure. On the other hand, chronic postnatal stress, mediated by MS, significantly impaired learning on the Place Navigation test. In addition, MS was associated with changes in search strategies on the Place Navigation, Probe, and Memory Recall tests. Specifically, postnatal stress increased thigmotaxis, indica...Continue Reading

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Citations

Aug 17, 2019·Frontiers in Neuroscience·Hana ZoubkováRomana Šlamberová
May 18, 2021·Frontiers in Behavioral Neuroscience·Anna Holubová-Kroupová, Romana Šlamberová

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