Early postnatal stress suppresses the developmental trajectory of hippocampal pyramidal neurons: the role of CRHR1

Brain Structure & Function
Rui LiuTian-Mei Si

Abstract

Adverse experiences early in life hamper the development and maturation of the hippocampus, but how early-life stress perturbs the developmental trajectory of the hippocampus across various life stages and the underlying molecular mechanisms remain to be investigated. In this study, we stressed male mice from postnatal day 2 (P2) to P9, and examined the potential role of CRHR1 in postnatal stress-induced structural remodeling of hippocampal CA3 pyramidal neurons directly after stress (P9), in mid-adolescence (P35) and in adulthood (P90). We found that early-life stress exposure significantly reduced apical dendritic arborization and spine density in CA3 neurons on P9 and P90. Moreover, postnatally stressed neurons underwent increased pruning of spines, especially thin spines, between P35 and P90. These stress-induced immediate and long-term structural abnormalities could be abolished by daily systemic administration of the CRHR1 antagonist antalarmin (20 µg/g of body weight) during stress exposure. However, such treatment strategy failed to attenuate the deleterious stress effects in mid-adolescence on P35. We then extended antalarmin treatment until the end of the second postnatal week, and found that prolonged blockade of CRH...Continue Reading

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Citations

Sep 1, 2018·The International Journal of Neuropsychopharmacology·Han WangYun-Ai Su
May 18, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Arunima RoyJaanus Harro
Feb 2, 2021·The FEBS Journal·Praachi TiwariVidita A Vaidya
Aug 20, 2021·Frontiers in Endocrinology·Ifigeneia KassotakiDimitris K Grammatopoulos

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