Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development

PloS One
Kaichi YoshizakiNoriko Osumi

Abstract

The understanding of individual diversity and its link to brain functions is a fundamental issue in neurobiology. Studies in mice have mainly focused on the investigation of behavior traits in adulthood, whereas longitudinal analyses are largely uninvestigated. Here we have conducted systematic behavior tests in individual mice (C57BL6/J, male), comparing phenotypes at early postnatal stages and in adulthood. Each animal showed different scores in individual behavior tests. However, we observed an inverse correlation between repetitive behavior in the Morris water maze test and sociability in the 3-chamber social interaction test; an increase in repetitive behaviors was associated with poor sociability. In longitudinal analyses, the emission of ultrasonic vocalization during maternal separation at postnatal day 6 in pups was correlated positively with sociability and negatively with spatial memory. Our results show a possibility that individual differences in communication between pups and their mother in infancy is a predictive indicator for sociability and cognitive performance as an adult.

References

Sep 28, 1992·Behavioural Brain Research·I Brouette-LahlouM Vigouroux
Oct 2, 1991·European Journal of Pharmacology·T R Insel, J T Winslow
Mar 16, 1993·European Journal of Pharmacology·J T Winslow, T R Insel
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M HoltzmanW C Mobley
Aug 12, 1999·Behavioral Neuroscience·D BrunnerM Hofer
Jun 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Weiguo ShuJoseph D Buxbaum
Dec 20, 2005·Pharmacology, Biochemistry, and Behavior·Michihiko Iijima, Shigeyuki Chaki
Mar 18, 2006·Neuroreport·Jonathan D PickerJoanne Berger-Sweeney
Sep 30, 2006·Human Molecular Genetics·Ichiko NishijimaAllan Bradley
Aug 25, 2007·Physiology & Behavior·Cindy K BarhaLiisa A M Galea
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stephane JamainNils Brose
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Maria Luisa ScattoniLaura Ricceri
Feb 19, 2011·Psychopharmacology·Li WangStephanie C Dulawa
Aug 24, 2011·Psychological Bulletin·Eric Turkheimer
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nannan GuoNoriko Osumi
Mar 13, 2014·The Journal of Clinical Investigation·Valter TucciPatrick M Nolan
Apr 22, 2015·Cognitive, Affective & Behavioral Neuroscience·Daria Peleg-RaibsteinBenjamin K Yee
Jan 30, 2016·Molecular Brain·Hirotaka ShojiTsuyoshi Miyakawa
May 7, 2016·Nature Reviews. Neuroscience·Annie Vogel Ciernia, Janine LaSalle
Sep 8, 2016·Nature·Yuta KatayamaKeiichi I Nakayama
Apr 20, 2017·Genes, Brain, and Behavior·G Lassi, V Tucci

❮ Previous
Next ❯

Citations

Aug 1, 2018·Annals of the New York Academy of Sciences·Jamela JoudaAdriana Del Rey
Jun 19, 2019·Developmental Psychobiology·Aurélie VerjatChristophe Féron
Jan 6, 2021·EMBO Reports·Kaichi YoshizakiNoriko Osumi

❮ Previous
Next ❯

Methods Mentioned

BETA
chip

Software Mentioned

SR
Any
LAB
WaterMaze

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.