Early postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up

Endocrine
Kristin Astrid ØysteseJens Bollerslev

Abstract

Non-functioning pituitary adenomas are common, and the treatment and follow-up of these patients represent a multidisciplinary challenge. First line treatment is transphenoidal surgery, with debulking or total removal of tumour. A substantial portion of the tumours relapse after surgery, and there is no consensus of how to follow these patients postoperatively. Our aim was to characterize the postoperative growth of non-functioning pituitary adenomas and correlate it to clinical and paraclinical data. We retrospectively registered 52 patients operated for non-functioning pituitary adenomas, with four or more consecutive MR-investigations not interrupted by secondary treatment. Adenoma volumes were estimated by the Cavalieri principle with summation of manually drawn areas multiplied by slice interval. Growth curves were modelled and tumour volume doubling time was calculated for 39 tumours with regrowth after surgery. A total of 13 tumours showed exponential growth, 10 linear growth and 16 logistic growth after surgery. The remaining 13 did not show regrowth of tumour. Seven of the exponential growing tumours underwent secondary surgery, compared to one and two of linear and logistic growing tumours (p = 0.03), respectively. In...Continue Reading

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Citations

Dec 21, 2017·European Journal of Endocrinology·Camilla Maria FalchNicoleta Cristina Olarescu
May 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Anders J KolnesAnders P Jørgensen
Sep 28, 2018·Endocrine·Kristin Astrid Berland ØysteseGeir Ringstad
Dec 25, 2017·Pituitary·Emilija Manojlovic-GacicOlivera Casar-Borota
Mar 29, 2021·Clinical Endocrinology·Nèle F LendersAnn I McCormack

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